BDBM150893 US8981106, 82

SMILES: CCOP(=O)(CSc1ccc(cn1)C(=O)Nc1ccc(F)cc1)OCC

InChI Key: InChIKey=XMNHEEWHKYYPOZ-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 150893   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
C-X-C chemokine receptor type 2 (Homo sapiens (Human))	BDBM150893 (US8981106, 82) Show SMILES CCOP(=O)(CSc1ccc(cn1)C(=O)Nc1ccc(F)cc1)OCC Show InChI InChI=1S/C17H20FN2O4PS/c1-3-23-25(22,24-4-2)12-26-16-10-5-13(11-19-16)17(21)20-15-8-6-14(18)7-9-15/h5-11H,3-4,12H2,1-2H3,(H,20,21)	PDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Syntrix Biosystems Curated by ChEMBL					Assay Description Antagonist activity at CXCR2 in human PMNs assessed as inhibition of CXCL1-induced intracellular Ca2+ release by fluorescence based calcium flux assa...				J Med Chem 57: 8378-97 (2014) Article DOI: 10.1021/jm500827t BindingDB Entry DOI: 10.7270/Q2FX7C22
					More data for this Ligand-Target Pair
C-X-C chemokine receptor type 2 (Homo sapiens (Human))	BDBM150893 (US8981106, 82) Show SMILES CCOP(=O)(CSc1ccc(cn1)C(=O)Nc1ccc(F)cc1)OCC Show InChI InChI=1S/C17H20FN2O4PS/c1-3-23-25(22,24-4-2)12-26-16-10-5-13(11-19-16)17(21)20-15-8-6-14(18)7-9-15/h5-11H,3-4,12H2,1-2H3,(H,20,21)	PDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	37
Syntrix Biosystems, Inc. US Patent					Assay Description An in vitro assay showed inhibition of CXCR2-mediated intracellular calcium release. Briefly, human neutrophils were suspended in HBSS- (without Ca2+...				US Patent US8981106 (2015) BindingDB Entry DOI: 10.7270/Q2WW7GC1
					More data for this Ligand-Target Pair