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BDBM151331 US8987314, B129

SMILES: Cc1cc2nc(sc2cc1-c1ccc(F)nc1)C(C(=O)NCCS(N)(=O)=O)S(C)(=O)=O

InChI Key: InChIKey=GTXFFILZLINOAH-UHFFFAOYNA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 151331   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Hepatic Lipase (HL)


(Homo sapiens (Human))
BDBM151331
PNG
(US8987314, B129)
Show SMILES Cc1cc2nc(sc2cc1-c1ccc(F)nc1)C(C(=O)NCCS(N)(=O)=O)S(C)(=O)=O
Show InChI InChI=1/C18H19FN4O5S3/c1-10-7-13-14(8-12(10)11-3-4-15(19)22-9-11)29-18(23-13)16(30(2,25)26)17(24)21-5-6-31(20,27)28/h3-4,7-9,16H,5-6H2,1-2H3,(H,21,24)(H2,20,27,28)
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a<10n/an/an/an/a8.025



Bristol-Myers Squibb Company

US Patent


Assay Description
Endothelial lipase (EL) and hepatic lipase (HL) activities were measured using a fluorescent substrate, A10070, (Invitrogen, CA) doped into an artifi...


US Patent US8987314 (2015)


BindingDB Entry DOI: 10.7270/Q2W094N8
More data for this
Ligand-Target Pair
Endothelial lipase


(Homo sapiens (Human))
BDBM151331
PNG
(US8987314, B129)
Show SMILES Cc1cc2nc(sc2cc1-c1ccc(F)nc1)C(C(=O)NCCS(N)(=O)=O)S(C)(=O)=O
Show InChI InChI=1/C18H19FN4O5S3/c1-10-7-13-14(8-12(10)11-3-4-15(19)22-9-11)29-18(23-13)16(30(2,25)26)17(24)21-5-6-31(20,27)28/h3-4,7-9,16H,5-6H2,1-2H3,(H,21,24)(H2,20,27,28)
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a<10n/an/an/an/a8.025



Bristol-Myers Squibb Company

US Patent


Assay Description
Endothelial lipase (EL) and hepatic lipase (HL) activities were measured using a fluorescent substrate, A10070, (Invitrogen, CA) doped into an artifi...


US Patent US8987314 (2015)


BindingDB Entry DOI: 10.7270/Q2W094N8
More data for this
Ligand-Target Pair