BDBM15137 3-[(2S)-2-amino-3-{[5-(3-methyl-1H-indazol-5-yl)pyridin-3-yl]oxy}propyl]quinoline::5-indazolyl pyridine 11f

SMILES: Cc1n[nH]c2ccc(cc12)-c1cncc(OC[C@@H](N)Cc2cnc3ccccc3c2)c1

InChI Key: InChIKey=NRBLWRZCVUTONX-NRFANRHFSA-N

Data: 1 KI

PDB links: 3 PDB IDs contain inhibitors having a similarity of 90% to this monomer.

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 15137   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Protein kinase B (Akt 1) (Homo sapiens (Human))	BDBM15137 (3-[(2S)-2-amino-3-{[5-(3-methyl-1H-indazol-5-yl)py...) Show SMILES Cc1n[nH]c2ccc(cc12)-c1cncc(OC[C@@H](N)Cc2cnc3ccccc3c2)c1 |r| Show InChI InChI=1S/C25H23N5O/c1-16-23-11-18(6-7-25(23)30-29-16)20-10-22(14-27-13-20)31-15-21(26)9-17-8-19-4-2-3-5-24(19)28-12-17/h2-8,10-14,21H,9,15,26H2,1H3,(H,29,30)/t21-/m0/s1	PDB MMDB B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	185	-9.09	n/a	n/a	n/a	n/a	n/a	7.5	22
Abbott Laboratories					Assay Description The kinase assay uses His-Akt1 and a biotinylated peptide as substrate. The biotinylated peptides were immobilized on streptavidin-coated FLASH plat...				Bioorg Med Chem Lett 16: 3740-4 (2006) Article DOI: 10.1016/j.bmcl.2006.04.046 BindingDB Entry DOI: 10.7270/Q2ZP44C9
					More data for this Ligand-Target Pair