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BDBM151421 US8987314, B232

SMILES: COCCS(=O)(=O)C(C(=O)NCc1cc(no1)C(C)C)c1nc2ccc(cc2s1)-c1ccccc1

InChI Key: InChIKey=CFCIABYWOHTXJM-UHFFFAOYNA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 151421   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Hepatic Lipase (HL)


(Homo sapiens (Human))
BDBM151421
PNG
(US8987314, B232)
Show SMILES COCCS(=O)(=O)C(C(=O)NCc1cc(no1)C(C)C)c1nc2ccc(cc2s1)-c1ccccc1
Show InChI InChI=1/C25H27N3O5S2/c1-16(2)21-14-19(33-28-21)15-26-24(29)23(35(30,31)12-11-32-3)25-27-20-10-9-18(13-22(20)34-25)17-7-5-4-6-8-17/h4-10,13-14,16,23H,11-12,15H2,1-3H3,(H,26,29)
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 0.800n/an/an/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
Endothelial lipase (EL) and hepatic lipase (HL) activities were measured using a fluorescent substrate, A10070, (Invitrogen, CA) doped into an artifi...


Citation and Details
More data for this
Ligand-Target Pair
Endothelial lipase (EL)


(Homo sapiens (Human))
BDBM151421
PNG
(US8987314, B232)
Show SMILES COCCS(=O)(=O)C(C(=O)NCc1cc(no1)C(C)C)c1nc2ccc(cc2s1)-c1ccccc1
Show InChI InChI=1/C25H27N3O5S2/c1-16(2)21-14-19(33-28-21)15-26-24(29)23(35(30,31)12-11-32-3)25-27-20-10-9-18(13-22(20)34-25)17-7-5-4-6-8-17/h4-10,13-14,16,23H,11-12,15H2,1-3H3,(H,26,29)
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 45.9n/an/an/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
Endothelial lipase (EL) and hepatic lipase (HL) activities were measured using a fluorescent substrate, A10070, (Invitrogen, CA) doped into an artifi...


Citation and Details
More data for this
Ligand-Target Pair