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BDBM151422 US8987314, B233

SMILES: Cc1cc(CNC(=O)C(c2nc3ccc(cc3s2)-c2ccccc2)S(C)(=O)=O)on1

InChI Key: InChIKey=GNQHHPXWQKZNIJ-UHFFFAOYNA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 151422   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Hepatic Lipase (HL)


(Homo sapiens (Human))
BDBM151422
PNG
(US8987314, B233)
Show SMILES Cc1cc(CNC(=O)C(c2nc3ccc(cc3s2)-c2ccccc2)S(C)(=O)=O)on1
Show InChI InChI=1/C21H19N3O4S2/c1-13-10-16(28-24-13)12-22-20(25)19(30(2,26)27)21-23-17-9-8-15(11-18(17)29-21)14-6-4-3-5-7-14/h3-11,19H,12H2,1-2H3,(H,22,25)
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 3.60n/an/an/an/a8.025



Bristol-Myers Squibb Company

US Patent


Assay Description
Endothelial lipase (EL) and hepatic lipase (HL) activities were measured using a fluorescent substrate, A10070, (Invitrogen, CA) doped into an artifi...


US Patent US8987314 (2015)


BindingDB Entry DOI: 10.7270/Q2W094N8
More data for this
Ligand-Target Pair
Endothelial lipase


(Homo sapiens (Human))
BDBM151422
PNG
(US8987314, B233)
Show SMILES Cc1cc(CNC(=O)C(c2nc3ccc(cc3s2)-c2ccccc2)S(C)(=O)=O)on1
Show InChI InChI=1/C21H19N3O4S2/c1-13-10-16(28-24-13)12-22-20(25)19(30(2,26)27)21-23-17-9-8-15(11-18(17)29-21)14-6-4-3-5-7-14/h3-11,19H,12H2,1-2H3,(H,22,25)
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 31.6n/an/an/an/a8.025



Bristol-Myers Squibb Company

US Patent


Assay Description
Endothelial lipase (EL) and hepatic lipase (HL) activities were measured using a fluorescent substrate, A10070, (Invitrogen, CA) doped into an artifi...


US Patent US8987314 (2015)


BindingDB Entry DOI: 10.7270/Q2W094N8
More data for this
Ligand-Target Pair