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BDBM151442 US8987314, B253

SMILES: Cc1nnc(CNC(=O)C(c2nc3ccc(cc3s2)-c2ccc(F)cc2)S(=O)(=O)Cc2ccccc2)o1

InChI Key: InChIKey=HJNZDAFULGBISM-UHFFFAOYNA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 151442   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Hepatic Lipase (HL)


(Homo sapiens (Human))
BDBM151442
PNG
(US8987314, B253)
Show SMILES Cc1nnc(CNC(=O)C(c2nc3ccc(cc3s2)-c2ccc(F)cc2)S(=O)(=O)Cc2ccccc2)o1
Show InChI InChI=1/C26H21FN4O4S2/c1-16-30-31-23(35-16)14-28-25(32)24(37(33,34)15-17-5-3-2-4-6-17)26-29-21-12-9-19(13-22(21)36-26)18-7-10-20(27)11-8-18/h2-13,24H,14-15H2,1H3,(H,28,32)
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 9.40n/an/an/an/a8.025



Bristol-Myers Squibb Company

US Patent


Assay Description
Endothelial lipase (EL) and hepatic lipase (HL) activities were measured using a fluorescent substrate, A10070, (Invitrogen, CA) doped into an artifi...


US Patent US8987314 (2015)


BindingDB Entry DOI: 10.7270/Q2W094N8
More data for this
Ligand-Target Pair
Endothelial lipase


(Homo sapiens (Human))
BDBM151442
PNG
(US8987314, B253)
Show SMILES Cc1nnc(CNC(=O)C(c2nc3ccc(cc3s2)-c2ccc(F)cc2)S(=O)(=O)Cc2ccccc2)o1
Show InChI InChI=1/C26H21FN4O4S2/c1-16-30-31-23(35-16)14-28-25(32)24(37(33,34)15-17-5-3-2-4-6-17)26-29-21-12-9-19(13-22(21)36-26)18-7-10-20(27)11-8-18/h2-13,24H,14-15H2,1H3,(H,28,32)
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 42.2n/an/an/an/a8.025



Bristol-Myers Squibb Company

US Patent


Assay Description
Endothelial lipase (EL) and hepatic lipase (HL) activities were measured using a fluorescent substrate, A10070, (Invitrogen, CA) doped into an artifi...


US Patent US8987314 (2015)


BindingDB Entry DOI: 10.7270/Q2W094N8
More data for this
Ligand-Target Pair