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BDBM151463 US8987314, B274

SMILES: Cc1cc2nc(sc2cc1-c1ccc(cc1)C(=O)OC(C)(C)C)C(C(=O)NCCS(N)(=O)=O)S(C)(=O)=O

InChI Key: InChIKey=YWCHTNSPNIFYNH-UHFFFAOYNA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 151463   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Hepatic Lipase (HL)


(Homo sapiens (Human))
BDBM151463
PNG
(US8987314, B274)
Show SMILES Cc1cc2nc(sc2cc1-c1ccc(cc1)C(=O)OC(C)(C)C)C(C(=O)NCCS(N)(=O)=O)S(C)(=O)=O
Show InChI InChI=1/C24H29N3O7S3/c1-14-12-18-19(13-17(14)15-6-8-16(9-7-15)23(29)34-24(2,3)4)35-22(27-18)20(36(5,30)31)21(28)26-10-11-37(25,32)33/h6-9,12-13,20H,10-11H2,1-5H3,(H,26,28)(H2,25,32,33)
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 5.10n/an/an/an/a8.025



Bristol-Myers Squibb Company

US Patent


Assay Description
Endothelial lipase (EL) and hepatic lipase (HL) activities were measured using a fluorescent substrate, A10070, (Invitrogen, CA) doped into an artifi...


US Patent US8987314 (2015)


BindingDB Entry DOI: 10.7270/Q2W094N8
More data for this
Ligand-Target Pair
Endothelial lipase


(Homo sapiens (Human))
BDBM151463
PNG
(US8987314, B274)
Show SMILES Cc1cc2nc(sc2cc1-c1ccc(cc1)C(=O)OC(C)(C)C)C(C(=O)NCCS(N)(=O)=O)S(C)(=O)=O
Show InChI InChI=1/C24H29N3O7S3/c1-14-12-18-19(13-17(14)15-6-8-16(9-7-15)23(29)34-24(2,3)4)35-22(27-18)20(36(5,30)31)21(28)26-10-11-37(25,32)33/h6-9,12-13,20H,10-11H2,1-5H3,(H,26,28)(H2,25,32,33)
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 1.70n/an/an/an/a8.025



Bristol-Myers Squibb Company

US Patent


Assay Description
Endothelial lipase (EL) and hepatic lipase (HL) activities were measured using a fluorescent substrate, A10070, (Invitrogen, CA) doped into an artifi...


US Patent US8987314 (2015)


BindingDB Entry DOI: 10.7270/Q2W094N8
More data for this
Ligand-Target Pair