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BDBM151465 US8987314, B276

SMILES: CC(C)(C)OC(=O)c1ccc(cc1)-c1ccc2nc(sc2c1)C(C(=O)NCCS(N)(=O)=O)S(=O)(=O)Cc1ccccc1

InChI Key: InChIKey=TZQNYSMYELNAHD-UHFFFAOYNA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 151465   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Hepatic Lipase (HL)


(Homo sapiens (Human))
BDBM151465
PNG
(US8987314, B276)
Show SMILES CC(C)(C)OC(=O)c1ccc(cc1)-c1ccc2nc(sc2c1)C(C(=O)NCCS(N)(=O)=O)S(=O)(=O)Cc1ccccc1
Show InChI InChI=1/C29H31N3O7S3/c1-29(2,3)39-28(34)21-11-9-20(10-12-21)22-13-14-23-24(17-22)40-27(32-23)25(26(33)31-15-16-42(30,37)38)41(35,36)18-19-7-5-4-6-8-19/h4-14,17,25H,15-16,18H2,1-3H3,(H,31,33)(H2,30,37,38)
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 0.800n/an/an/an/a8.025



Bristol-Myers Squibb Company

US Patent


Assay Description
Endothelial lipase (EL) and hepatic lipase (HL) activities were measured using a fluorescent substrate, A10070, (Invitrogen, CA) doped into an artifi...


US Patent US8987314 (2015)

More data for this
Ligand-Target Pair
Endothelial lipase


(Homo sapiens (Human))
BDBM151465
PNG
(US8987314, B276)
Show SMILES CC(C)(C)OC(=O)c1ccc(cc1)-c1ccc2nc(sc2c1)C(C(=O)NCCS(N)(=O)=O)S(=O)(=O)Cc1ccccc1
Show InChI InChI=1/C29H31N3O7S3/c1-29(2,3)39-28(34)21-11-9-20(10-12-21)22-13-14-23-24(17-22)40-27(32-23)25(26(33)31-15-16-42(30,37)38)41(35,36)18-19-7-5-4-6-8-19/h4-14,17,25H,15-16,18H2,1-3H3,(H,31,33)(H2,30,37,38)
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 1.10n/an/an/an/a8.025



Bristol-Myers Squibb Company

US Patent


Assay Description
Endothelial lipase (EL) and hepatic lipase (HL) activities were measured using a fluorescent substrate, A10070, (Invitrogen, CA) doped into an artifi...


US Patent US8987314 (2015)

More data for this
Ligand-Target Pair