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BDBM151468 US8987314, B279

SMILES: Cc1nnc(CNC(=O)C(c2nc3ccc(cc3s2)-c2ccc(cc2)C(=O)OC(C)(C)C)S(C)(=O)=O)s1

InChI Key: InChIKey=SYAPLKNCGPHOGB-UHFFFAOYNA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 151468   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Hepatic Lipase (HL)


(Homo sapiens (Human))
BDBM151468
PNG
(US8987314, B279)
Show SMILES Cc1nnc(CNC(=O)C(c2nc3ccc(cc3s2)-c2ccc(cc2)C(=O)OC(C)(C)C)S(C)(=O)=O)s1
Show InChI InChI=1/C25H26N4O5S3/c1-14-28-29-20(35-14)13-26-22(30)21(37(5,32)33)23-27-18-11-10-17(12-19(18)36-23)15-6-8-16(9-7-15)24(31)34-25(2,3)4/h6-12,21H,13H2,1-5H3,(H,26,30)
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 2.80n/an/an/an/a8.025



Bristol-Myers Squibb Company

US Patent


Assay Description
Endothelial lipase (EL) and hepatic lipase (HL) activities were measured using a fluorescent substrate, A10070, (Invitrogen, CA) doped into an artifi...


US Patent US8987314 (2015)


BindingDB Entry DOI: 10.7270/Q2W094N8
More data for this
Ligand-Target Pair
Endothelial lipase


(Homo sapiens (Human))
BDBM151468
PNG
(US8987314, B279)
Show SMILES Cc1nnc(CNC(=O)C(c2nc3ccc(cc3s2)-c2ccc(cc2)C(=O)OC(C)(C)C)S(C)(=O)=O)s1
Show InChI InChI=1/C25H26N4O5S3/c1-14-28-29-20(35-14)13-26-22(30)21(37(5,32)33)23-27-18-11-10-17(12-19(18)36-23)15-6-8-16(9-7-15)24(31)34-25(2,3)4/h6-12,21H,13H2,1-5H3,(H,26,30)
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 15.6n/an/an/an/a8.025



Bristol-Myers Squibb Company

US Patent


Assay Description
Endothelial lipase (EL) and hepatic lipase (HL) activities were measured using a fluorescent substrate, A10070, (Invitrogen, CA) doped into an artifi...


US Patent US8987314 (2015)


BindingDB Entry DOI: 10.7270/Q2W094N8
More data for this
Ligand-Target Pair