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BDBM151496 US8987314, B307

SMILES: NS(=O)(=O)CCNC(=O)C(c1nc2ccc(cc2s1)-c1ccccc1F)S(=O)(=O)CCC(F)(F)F

InChI Key: InChIKey=FQAITXRGECDYOU-UHFFFAOYNA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 151496   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Hepatic Lipase (HL)


(Homo sapiens (Human))
BDBM151496
PNG
(US8987314, B307)
Show SMILES NS(=O)(=O)CCNC(=O)C(c1nc2ccc(cc2s1)-c1ccccc1F)S(=O)(=O)CCC(F)(F)F
Show InChI InChI=1/C20H19F4N3O5S3/c21-14-4-2-1-3-13(14)12-5-6-15-16(11-12)33-19(27-15)17(18(28)26-8-10-35(25,31)32)34(29,30)9-7-20(22,23)24/h1-6,11,17H,7-10H2,(H,26,28)(H2,25,31,32)
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 1.5n/an/an/an/a8.025



Bristol-Myers Squibb Company

US Patent


Assay Description
Endothelial lipase (EL) and hepatic lipase (HL) activities were measured using a fluorescent substrate, A10070, (Invitrogen, CA) doped into an artifi...


US Patent US8987314 (2015)

More data for this
Ligand-Target Pair
Endothelial lipase


(Homo sapiens (Human))
BDBM151496
PNG
(US8987314, B307)
Show SMILES NS(=O)(=O)CCNC(=O)C(c1nc2ccc(cc2s1)-c1ccccc1F)S(=O)(=O)CCC(F)(F)F
Show InChI InChI=1/C20H19F4N3O5S3/c21-14-4-2-1-3-13(14)12-5-6-15-16(11-12)33-19(27-15)17(18(28)26-8-10-35(25,31)32)34(29,30)9-7-20(22,23)24/h1-6,11,17H,7-10H2,(H,26,28)(H2,25,31,32)
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 3n/an/an/an/a8.025



Bristol-Myers Squibb Company

US Patent


Assay Description
Endothelial lipase (EL) and hepatic lipase (HL) activities were measured using a fluorescent substrate, A10070, (Invitrogen, CA) doped into an artifi...


US Patent US8987314 (2015)

More data for this
Ligand-Target Pair