BDBM152276 US8993556, 5-[2,4-Dihydroxy-6-(4-nitrophenoxy)phenyl]-N-[1-(propan-2-yl)piperidin-4-yl]isoxazole-3-carboxamide

SMILES: CC(C)N1CCC(CC1)NC(=O)c1cc(on1)-c1c(O)cc(O)cc1Oc1ccc(cc1)[N+]([O-])=O

InChI Key: InChIKey=MRYIXDMUJARPCG-UHFFFAOYSA-N

Data: 1 Kd

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 152276   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Heat shock protein HSP 90-alpha (Homo sapiens (Human))	BDBM152276 (US8993556, 5-[2,4-Dihydroxy-6-(4-nitrophenoxy)phen...) Show SMILES CC(C)N1CCC(CC1)NC(=O)c1cc(on1)-c1c(O)cc(O)cc1Oc1ccc(cc1)[N+]([O-])=O Show InChI InChI=1S/C24H26N4O7/c1-14(2)27-9-7-15(8-10-27)25-24(31)19-13-22(35-26-19)23-20(30)11-17(29)12-21(23)34-18-5-3-16(4-6-18)28(32)33/h3-6,11-15,29-30H,7-10H2,1-2H3,(H,25,31)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	n/a	3.20	n/a	n/a	n/a	7.6	n/a
Nerviano Medical Sciences S.R.L. US Patent					Assay Description The evaluation of the binding affinity (KD) of the compounds of formula (I) to the HSP90 protein was done using Biacore T100.His-HSP90 N-term domain ...				US Patent US8993556 (2015) BindingDB Entry DOI: 10.7270/Q2Q81BSQ
					More data for this Ligand-Target Pair