BDBM15237 4-[1-(cyclopropylmethyl)-4-(4-fluorophenyl)-1H-imidazol-5-yl]pyridine::CHEMBL96741::PYRIDINYLIMIDAZOLE::SB2::SB216995

SMILES: Fc1ccc(cc1)-c1ncn(CC2CC2)c1-c1ccncc1

InChI Key: InChIKey=ROKOFZNQCIIJMI-UHFFFAOYSA-N

Data: 6 IC50

PDB links: 1 PDB ID matches this monomer.

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 15237   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Mitogen-activated protein kinase 14 (Homo sapiens (Human))	BDBM15237 (4-[1-(cyclopropylmethyl)-4-(4-fluorophenyl)-1H-imi...) Show SMILES Fc1ccc(cc1)-c1ncn(CC2CC2)c1-c1ccncc1 Show InChI InChI=1S/C18H16FN3/c19-16-5-3-14(4-6-16)17-18(15-7-9-20-10-8-15)22(12-21-17)11-13-1-2-13/h3-10,12-13H,1-2,11H2	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL DrugBank MMDB PC cid PC sid PDB UniChem Patents Similars	DrugBank MMDB Article PubMed	n/a	n/a	160	n/a	n/a	n/a	n/a	7.5	37
University of Texas Southwestern Medical Center at Dallas					Assay Description Kinase activity was assayed in reaction buffer containing substrate, enzyme, and inhibitor in the presence of 0.17 mM ATP/[gamma-32P] ATP. 32P incorp...				Structure 6: 1117-28 (1998) Article DOI: 10.1016/s0969-2126(98)00113-0 BindingDB Entry DOI: 10.7270/Q2XP7351
					More data for this Ligand-Target Pair				3D Structure (docked)
ERK-2 (Rattus norvegicus (rat))	BDBM15237 (4-[1-(cyclopropylmethyl)-4-(4-fluorophenyl)-1H-imi...) Show SMILES Fc1ccc(cc1)-c1ncn(CC2CC2)c1-c1ccncc1 Show InChI InChI=1S/C18H16FN3/c19-16-5-3-14(4-6-16)17-18(15-7-9-20-10-8-15)22(12-21-17)11-13-1-2-13/h3-10,12-13H,1-2,11H2	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL DrugBank MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	7.5	37
University of Texas Southwestern Medical Center at Dallas					Assay Description Kinase activity was assayed in reaction buffer containing substrate, enzyme, and inhibitor in the presence of 0.17 mM ATP/[gamma-32P] ATP. 32P incorp...				Structure 6: 1117-28 (1998) Article DOI: 10.1016/s0969-2126(98)00113-0 BindingDB Entry DOI: 10.7270/Q2XP7351
					More data for this Ligand-Target Pair				3D Structure (docked)
Mitogen-activated protein kinase 14 (Homo sapiens (Human))	BDBM15237 (4-[1-(cyclopropylmethyl)-4-(4-fluorophenyl)-1H-imi...) Show SMILES Fc1ccc(cc1)-c1ncn(CC2CC2)c1-c1ccncc1 Show InChI InChI=1S/C18H16FN3/c19-16-5-3-14(4-6-16)17-18(15-7-9-20-10-8-15)22(12-21-17)11-13-1-2-13/h3-10,12-13H,1-2,11H2	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL DrugBank MMDB PC cid PC sid PDB UniChem Patents Similars	DrugBank MMDB Article PubMed	n/a	n/a	160	n/a	n/a	n/a	n/a	n/a	n/a
King's College London Curated by ChEMBL					Assay Description Inhibition of human MAPK p38alpha				Bioorg Med Chem 18: 2204-18 (2010) Article DOI: 10.1016/j.bmc.2010.01.070 BindingDB Entry DOI: 10.7270/Q27945MJ
					More data for this Ligand-Target Pair				3D Structure (docked)
Mitogen-activated protein kinase 14 (Homo sapiens (Human))	BDBM15237 (4-[1-(cyclopropylmethyl)-4-(4-fluorophenyl)-1H-imi...) Show SMILES Fc1ccc(cc1)-c1ncn(CC2CC2)c1-c1ccncc1 Show InChI InChI=1S/C18H16FN3/c19-16-5-3-14(4-6-16)17-18(15-7-9-20-10-8-15)22(12-21-17)11-13-1-2-13/h3-10,12-13H,1-2,11H2	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL DrugBank MMDB PC cid PC sid PDB UniChem Patents Similars	DrugBank MMDB Article PubMed	n/a	n/a	160	n/a	n/a	n/a	n/a	n/a	n/a
Eberhard-Karls-University Tübingen Curated by ChEMBL					Assay Description Inhibition of p38alpha MAPK by non-radioactive immunosorbent assay				J Med Chem 50: 1213-21 (2007) Article DOI: 10.1021/jm061097o BindingDB Entry DOI: 10.7270/Q2QZ29NS
					More data for this Ligand-Target Pair				3D Structure (docked)
Arachidonate 5-lipoxygenase (Rattus norvegicus)	BDBM15237 (4-[1-(cyclopropylmethyl)-4-(4-fluorophenyl)-1H-imi...) Show SMILES Fc1ccc(cc1)-c1ncn(CC2CC2)c1-c1ccncc1 Show InChI InChI=1S/C18H16FN3/c19-16-5-3-14(4-6-16)17-18(15-7-9-20-10-8-15)22(12-21-17)11-13-1-2-13/h3-10,12-13H,1-2,11H2	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL DrugBank MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
SmithKline Beecham Pharmaceuticals Curated by ChEMBL					Assay Description Inhibitory concentration against 5-lipoxygenase in rat RBL-1 cells				J Med Chem 39: 3929-37 (1996) Article DOI: 10.1021/jm960415o BindingDB Entry DOI: 10.7270/Q29W0G4Z
					More data for this Ligand-Target Pair
Prostaglandin G/H synthase (cyclooxygenase) (Ovis aries (Sheep))	BDBM15237 (4-[1-(cyclopropylmethyl)-4-(4-fluorophenyl)-1H-imi...) Show SMILES Fc1ccc(cc1)-c1ncn(CC2CC2)c1-c1ccncc1 Show InChI InChI=1S/C18H16FN3/c19-16-5-3-14(4-6-16)17-18(15-7-9-20-10-8-15)22(12-21-17)11-13-1-2-13/h3-10,12-13H,1-2,11H2	PDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL DrugBank MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	5.10E+4	n/a	n/a	n/a	n/a	n/a	n/a
SmithKline Beecham Pharmaceuticals Curated by ChEMBL					Assay Description Inhibitory concentration against Prostaglandin H2 synthase 1 (PGHS-1) from ram seminal vesicle				J Med Chem 39: 3929-37 (1996) Article DOI: 10.1021/jm960415o BindingDB Entry DOI: 10.7270/Q29W0G4Z
					More data for this Ligand-Target Pair