BindingDB PrimarySearch

BDBM152638 4-(1,3-Dioxoisoindolin-2-yl)benzenesulphonamide (1)::BDBM50222606

SMILES: NS(=O)(=O)c1ccc(cc1)N1C(=O)c2ccccc2C1=O

InChI Key: InChIKey=YSJYDNVXXPFJIF-UHFFFAOYSA-N

Data: 8 KI 3 IC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 11 hits for monomerid = 152638
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Carbonic anhydrase 12 (Homo sapiens (Human))	BDBM152638 (4-(1,3-Dioxoisoindolin-2-yl)benzenesulphonamide (1...) Show SMILES NS(=O)(=O)c1ccc(cc1)N1C(=O)c2ccccc2C1=O Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase PC cid PC sid UniChem Similars	Article PubMed	0.530	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
King Saud University Curated by ChEMBL					Assay Description Inhibition of human carbonic anhydrase 12 by stopped-flow CO2 hydrase assay				Bioorg Med Chem Lett 24: 5185-9 (2014) Article DOI: 10.1016/j.bmcl.2014.09.076 BindingDB Entry DOI: 10.7270/Q25Q4XP2
King Saud University Curated by ChEMBL					More data for this Ligand-Target Pair
Carbonic anhydrase 2 (Homo sapiens (Human))	BDBM152638 (4-(1,3-Dioxoisoindolin-2-yl)benzenesulphonamide (1...) Show SMILES NS(=O)(=O)c1ccc(cc1)N1C(=O)c2ccccc2C1=O Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase PC cid PC sid UniChem Similars	Article PubMed	2.20	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
King Saud University Curated by ChEMBL					Assay Description Inhibition of human carbonic anhydrase 2 by stopped-flow CO2 hydrase assay				Bioorg Med Chem Lett 24: 5185-9 (2014) Article DOI: 10.1016/j.bmcl.2014.09.076 BindingDB Entry DOI: 10.7270/Q25Q4XP2
King Saud University Curated by ChEMBL					More data for this Ligand-Target Pair
Carbonic anhydrase 9 (Homo sapiens (Human))	BDBM152638 (4-(1,3-Dioxoisoindolin-2-yl)benzenesulphonamide (1...) Show SMILES NS(=O)(=O)c1ccc(cc1)N1C(=O)c2ccccc2C1=O Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase PC cid PC sid UniChem Similars	Article PubMed	3.80	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
King Saud University Curated by ChEMBL					Assay Description Inhibition of human carbonic anhydrase 9 by stopped-flow CO2 hydrase assay				Bioorg Med Chem Lett 24: 5185-9 (2014) Article DOI: 10.1016/j.bmcl.2014.09.076 BindingDB Entry DOI: 10.7270/Q25Q4XP2
King Saud University Curated by ChEMBL					More data for this Ligand-Target Pair
Carbonic anhydrase 1 (Homo sapiens (Human))	BDBM152638 (4-(1,3-Dioxoisoindolin-2-yl)benzenesulphonamide (1...) Show SMILES NS(=O)(=O)c1ccc(cc1)N1C(=O)c2ccccc2C1=O Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase PC cid PC sid UniChem Similars	Article PubMed	29	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
King Saud University Curated by ChEMBL					Assay Description Inhibition of human carbonic anhydrase 1 by stopped-flow CO2 hydrase assay				Bioorg Med Chem Lett 24: 5185-9 (2014) Article DOI: 10.1016/j.bmcl.2014.09.076 BindingDB Entry DOI: 10.7270/Q25Q4XP2
King Saud University Curated by ChEMBL					More data for this Ligand-Target Pair
Carbonic anhydrase 2 (Homo sapiens (Human))	BDBM152638 (4-(1,3-Dioxoisoindolin-2-yl)benzenesulphonamide (1...) Show SMILES NS(=O)(=O)c1ccc(cc1)N1C(=O)c2ccccc2C1=O Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase PC cid PC sid UniChem Similars	PubMed	42	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
A.P.S. University Curated by ChEMBL					Assay Description Inhibition of human carbonic anhydrase II (CAII)				Bioorg Med Chem Lett 13: 447-53 (2003) BindingDB Entry DOI: 10.7270/Q2668GC9
A.P.S. University Curated by ChEMBL					More data for this Ligand-Target Pair
Carbonic anhydrase (Bos taurus (bovine))	BDBM152638 (4-(1,3-Dioxoisoindolin-2-yl)benzenesulphonamide (1...) Show SMILES NS(=O)(=O)c1ccc(cc1)N1C(=O)c2ccccc2C1=O Show InChI	Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase PC cid PC sid UniChem Similars	PubMed	79	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
A.P.S. University Curated by ChEMBL					Assay Description Inhibition of bovine carbonic anhydrase IV (CAIV)				Bioorg Med Chem Lett 13: 447-53 (2003) BindingDB Entry DOI: 10.7270/Q2668GC9
A.P.S. University Curated by ChEMBL					More data for this Ligand-Target Pair
Carbonic anhydrase 1 (Homo sapiens (Human))	BDBM152638 (4-(1,3-Dioxoisoindolin-2-yl)benzenesulphonamide (1...) Show SMILES NS(=O)(=O)c1ccc(cc1)N1C(=O)c2ccccc2C1=O Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase PC cid PC sid UniChem Similars	PubMed	1.04E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
A.P.S. University Curated by ChEMBL					Assay Description Inhibition of human carbonic anhydrase I (CAI)				Bioorg Med Chem Lett 13: 447-53 (2003) BindingDB Entry DOI: 10.7270/Q2668GC9
A.P.S. University Curated by ChEMBL					More data for this Ligand-Target Pair
Sodium channel protein type 2 alpha subunit (Homo sapiens (Human))	BDBM152638 (4-(1,3-Dioxoisoindolin-2-yl)benzenesulphonamide (1...) Show SMILES NS(=O)(=O)c1ccc(cc1)N1C(=O)c2ccccc2C1=O Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase PC cid PC sid UniChem Similars	Article	1.60E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Binding affinity to Nav 1.2 (unknown origin)				Citation and Details Article DOI: 10.1007/s00044-012-0256-y BindingDB Entry DOI: 10.7270/Q20P12XT
TBA					More data for this Ligand-Target Pair
DENV2 protease (NS2B-NS3) (Dengue virus 2 (Virus))	BDBM152638 (4-(1,3-Dioxoisoindolin-2-yl)benzenesulphonamide (1...) Show SMILES NS(=O)(=O)c1ccc(cc1)N1C(=O)c2ccccc2C1=O Show InChI	PDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	8.5	n/a
Birla Institute of Technology					Assay Description To measure the inhibitory activities of the compounds, the DENV2 NS2B-NS3 protease activities were measured in the presence of the compounds using Bz...				Bioorg Chem 62: 74-82 (2015) Article DOI: 10.1016/j.bioorg.2015.07.005 BindingDB Entry DOI: 10.7270/Q2VT1QTG
Birla Institute of Technology					More data for this Ligand-Target Pair
Prostaglandin G/H synthase (cyclooxygenase) (Ovis aries (Sheep))	BDBM152638 (4-(1,3-Dioxoisoindolin-2-yl)benzenesulphonamide (1...) Show SMILES NS(=O)(=O)c1ccc(cc1)N1C(=O)c2ccccc2C1=O Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.50E+4	n/a	n/a	n/a	n/a	n/a	n/a
King Saud University Curated by ChEMBL					Assay Description Inhibition of ovine COX2-mediated prostaglandin alpha production by enzyme immuno assay				Bioorg Med Chem Lett 23: 2601-5 (2013) Article DOI: 10.1016/j.bmcl.2013.02.107 BindingDB Entry DOI: 10.7270/Q2SJ1PHN
King Saud University Curated by ChEMBL					More data for this Ligand-Target Pair
Prostaglandin G/H synthase (cyclooxygenase) (Ovis aries (Sheep))	BDBM152638 (4-(1,3-Dioxoisoindolin-2-yl)benzenesulphonamide (1...) Show SMILES NS(=O)(=O)c1ccc(cc1)N1C(=O)c2ccccc2C1=O Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
King Saud University Curated by ChEMBL					Assay Description Inhibition of ovine COX1-mediated prostaglandin alpha production by enzyme immuno assay				Bioorg Med Chem Lett 23: 2601-5 (2013) Article DOI: 10.1016/j.bmcl.2013.02.107 BindingDB Entry DOI: 10.7270/Q2SJ1PHN
King Saud University Curated by ChEMBL					More data for this Ligand-Target Pair