BDBM152937 US8993612, 20

SMILES: FC(F)(F)c1cc(C2CC2)n(n1)-c1ccc(NC(=O)Cn2nnc3ccccc23)cc1

InChI Key: InChIKey=APTPBHDTLDJGDO-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 152937   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Calcium release-activated calcium channel protein 1 (Homo sapiens (Human))	BDBM152937 (US8993612, 20) Show SMILES FC(F)(F)c1cc(C2CC2)n(n1)-c1ccc(NC(=O)Cn2nnc3ccccc23)cc1 Show InChI InChI=1S/C21H17F3N6O/c22-21(23,24)19-11-18(13-5-6-13)30(27-19)15-9-7-14(8-10-15)25-20(31)12-29-17-4-2-1-3-16(17)26-28-29/h1-4,7-11,13H,5-6,12H2,(H,25,31)	KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	39.2	n/a	n/a	n/a	n/a	n/a	37
Rhizen Pharmaceuticals SA US Patent					Assay Description Inhibition of CRAC channels was determined following thapsigargin (Sigma, Cat # T9033) induced endoplasmic calcium release in Jurkat cells. (see Yasu...				US Patent US8993612 (2015) BindingDB Entry DOI: 10.7270/Q2CN72NK
					More data for this Ligand-Target Pair