BDBM153209 US8993756, 10-1

SMILES: CCOC(=O)c1c[nH]c2ncnc(-c3cccc(NS(=O)(=O)C=C)c3)c12

InChI Key: InChIKey=WWGASLJTUAXCRF-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 153209   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Tyrosine-protein kinase JAK2 (Homo sapiens (Human))	BDBM153209 (US8993756, 10-1) Show SMILES CCOC(=O)c1c[nH]c2ncnc(-c3cccc(NS(=O)(=O)C=C)c3)c12 Show InChI InChI=1S/C17H16N4O4S/c1-3-25-17(22)13-9-18-16-14(13)15(19-10-20-16)11-6-5-7-12(8-11)21-26(23,24)4-2/h4-10,21H,2-3H2,1H3,(H,18,19,20)	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase PC cid PC sid UniChem Similars	US Patent	n/a	n/a	>1.50E+3	n/a	n/a	n/a	n/a	n/a	25
Merck Sharp & Dohme Corp. US Patent					Assay Description The ability of compounds to inhibit the activity of JAKl, JAK2, JAK3, and Tyk2 was measured using a recombinant purified GST-tagged catalytic domain ...				US Patent US8993756 (2015) BindingDB Entry DOI: 10.7270/Q2VQ31DJ
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK3 (Homo sapiens (Human))	BDBM153209 (US8993756, 10-1) Show SMILES CCOC(=O)c1c[nH]c2ncnc(-c3cccc(NS(=O)(=O)C=C)c3)c12 Show InChI InChI=1S/C17H16N4O4S/c1-3-25-17(22)13-9-18-16-14(13)15(19-10-20-16)11-6-5-7-12(8-11)21-26(23,24)4-2/h4-10,21H,2-3H2,1H3,(H,18,19,20)	PDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase PC cid PC sid UniChem Similars	US Patent	n/a	n/a	0.0370	n/a	n/a	n/a	n/a	n/a	25
Merck Sharp & Dohme Corp. US Patent					Assay Description The ability of compounds to inhibit the activity of JAKl, JAK2, JAK3, and Tyk2 was measured using a recombinant purified GST-tagged catalytic domain ...				US Patent US8993756 (2015) BindingDB Entry DOI: 10.7270/Q2VQ31DJ
					More data for this Ligand-Target Pair