null
SMILES: COc1cccc(Nc2c(cnc3c(C)cc(cc23)-c2ccc3cnn(C)c3c2)C(N)=O)c1
InChI Key: InChIKey=YLVFCOMEWFCJKA-UHFFFAOYSA-N
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
cAMP-specific 3',5'-cyclic phosphodiesterase 4A (Homo sapiens (Human)) | BDBM153402 (4-((3-Methoxyphenyl)amino)-8-methyl-6-(1-methyl-1H...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 8.30E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Northeastern University | Assay Description This assay was performed at Takeda Pharmaceuticals using methods previously reported. | Chem Biol Drug Des 85: 549-64 (2015) Article DOI: 10.1111/cbdd.12443 BindingDB Entry DOI: 10.7270/Q2FF3R28 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Phosphodiesterase (Trypanosoma brucei) | BDBM153402 (4-((3-Methoxyphenyl)amino)-8-methyl-6-(1-methyl-1H...) | PDB UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 3.10E+3 | n/a | n/a | n/a | n/a | 7.4 | n/a |
Northeastern University | Assay Description In short, recombinant TbrPDEB1 and TbrPDEB2 were assayed in 10 mM Tris pH 7.4, bovine serum albumin (0.2 mg/mL), 10 mM MgCl2, 25µM cAMP (Enzo Lifesci... | Chem Biol Drug Des 85: 549-64 (2015) Article DOI: 10.1111/cbdd.12443 BindingDB Entry DOI: 10.7270/Q2FF3R28 | |||||||||||
More data for this Ligand-Target Pair |