BDBM15356 1-naphthalen-1-yl-3-[2-(trifluoromethyl)phenyl]urea::SPECS compound no. 11
SMILES: FC(F)(F)c1ccccc1NC(=O)Nc1cccc2ccccc12
InChI Key: InChIKey=VSQZAFNNCVYGIM-UHFFFAOYSA-N
Data: 5 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Dihydroorotate Dehydrogenase (DHODH) (Plasmodium falciparum) | BDBM15356 (1-naphthalen-1-yl-3-[2-(trifluoromethyl)phenyl]ure...) | PDB MMDB KEGG UniProtKB/TrEMBL B.MOAD DrugBank GoogleScholar AffyNet | Purchase PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 400 | n/a | n/a | n/a | n/a | 8.0 | 22 |
University of Texas Southwestern Medical Center | Assay Description The assays were carried out by using a colorimetric DCIP method, which uses the colorimetric reagent 2, 6-dichlorophenolindophenol as the final elect... | J Biol Chem 280: 21847-53 (2005) Article DOI: 10.1074/jbc.M501100200 BindingDB Entry DOI: 10.7270/Q21G0JH3 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Dihydroorotate Dehydrogenase (DHODH) (Homo sapiens (Human)) | BDBM15356 (1-naphthalen-1-yl-3-[2-(trifluoromethyl)phenyl]ure...) | PDB MMDB Reactome pathway KEGG B.MOAD DrugBank GoogleScholar AffyNet | Purchase PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | >1.00E+6 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Texas Southwestern Medical Center | Assay Description The assays were carried out by using a colorimetric DCIP method, which uses the colorimetric reagent 2, 6-dichlorophenolindophenol as the final elect... | J Biol Chem 280: 21847-53 (2005) Article DOI: 10.1074/jbc.M501100200 BindingDB Entry DOI: 10.7270/Q21G0JH3 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Dihydroorotate dehydrogenase (quinone), mitochondrial (Plasmodium falciparum (isolate 3D7)) | BDBM15356 (1-naphthalen-1-yl-3-[2-(trifluoromethyl)phenyl]ure...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | Purchase PC cid PC sid UniChem Similars | Article | n/a | n/a | 200 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Inhibition of Plasmodium falciparum HIs6-tagged DHODH expressed in Escherichia coli DH5alpha using L-dihydroorotate as substrate by DCIP-based spectr... | Citation and Details Article DOI: 10.1007/s00044-010-9323-4 BindingDB Entry DOI: 10.7270/Q2JQ13W3 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Dihydroorotate Dehydrogenase (DHODH) Mutant (H185A) (Plasmodium falciparum) | BDBM15356 (1-naphthalen-1-yl-3-[2-(trifluoromethyl)phenyl]ure...) | PDB MMDB B.MOAD GoogleScholar AffyNet | Purchase PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | >2.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Texas Southwestern Medical Center | Assay Description The assays were carried out by using a colorimetric DCIP method, which uses the colorimetric reagent 2, 6-dichlorophenolindophenol as the final elect... | J Biol Chem 280: 21847-53 (2005) Article DOI: 10.1074/jbc.M501100200 BindingDB Entry DOI: 10.7270/Q21G0JH3 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Dihydroorotate Dehydrogenase (DHODH) Mutant (R265A) (Plasmodium falciparum) | BDBM15356 (1-naphthalen-1-yl-3-[2-(trifluoromethyl)phenyl]ure...) | PDB MMDB B.MOAD GoogleScholar AffyNet | Purchase PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 340 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Texas Southwestern Medical Center | Assay Description The assays were carried out by using a colorimetric DCIP method, which uses the colorimetric reagent 2, 6-dichlorophenolindophenol as the final elect... | J Biol Chem 280: 21847-53 (2005) Article DOI: 10.1074/jbc.M501100200 BindingDB Entry DOI: 10.7270/Q21G0JH3 | |||||||||||
More data for this Ligand-Target Pair |