BDBM154049 US9012443, 42

SMILES: COc1cc(ccc1-c1cccc2cc(ccc12)S(=O)(=O)Nc1ccncn1)C(F)(F)F

InChI Key: InChIKey=NYXYUZXPPILSFD-UHFFFAOYSA-N

Data: 3 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 154049   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Sodium channel protein type 9 subunit alpha (Homo sapiens (Human))	BDBM154049 (US9012443, 42) Show SMILES COc1cc(ccc1-c1cccc2cc(ccc12)S(=O)(=O)Nc1ccncn1)C(F)(F)F Show InChI InChI=1S/C22H16F3N3O3S/c1-31-20-12-15(22(23,24)25)5-7-19(20)18-4-2-3-14-11-16(6-8-17(14)18)32(29,30)28-21-9-10-26-13-27-21/h2-13H,1H3,(H,26,27,28)	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	50	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc. US Patent					Assay Description 293 Cells stably transfected with either Nav 1.7 or Nav 1.5 were recorded in population patch-clamp mode with the IonWorks Quattro automated electrop...				US Patent US9012443 (2015) BindingDB Entry DOI: 10.7270/Q2N0158J
					More data for this Ligand-Target Pair
Sodium channel protein type 9 subunit alpha (Homo sapiens (Human))	BDBM154049 (US9012443, 42) Show SMILES COc1cc(ccc1-c1cccc2cc(ccc12)S(=O)(=O)Nc1ccncn1)C(F)(F)F Show InChI InChI=1S/C22H16F3N3O3S/c1-31-20-12-15(22(23,24)25)5-7-19(20)18-4-2-3-14-11-16(6-8-17(14)18)32(29,30)28-21-9-10-26-13-27-21/h2-13H,1H3,(H,26,27,28)	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	510	n/a	n/a	n/a	n/a	n/a	n/a
Amgen, Inc. Curated by ChEMBL					Assay Description Inhibition of human Nav1.7 expressed in HEK293 cells assessed as inhibition of sodium current at holding potential of -125 mV measured for 3 to 5 min...				ACS Med Chem Lett 7: 1062-1067 (2016) Article DOI: 10.1021/acsmedchemlett.6b00243 BindingDB Entry DOI: 10.7270/Q2VM4F65
					More data for this Ligand-Target Pair
Sodium channel protein type 5 subunit alpha (Homo sapiens (Human))	BDBM154049 (US9012443, 42) Show SMILES COc1cc(ccc1-c1cccc2cc(ccc12)S(=O)(=O)Nc1ccncn1)C(F)(F)F Show InChI InChI=1S/C22H16F3N3O3S/c1-31-20-12-15(22(23,24)25)5-7-19(20)18-4-2-3-14-11-16(6-8-17(14)18)32(29,30)28-21-9-10-26-13-27-21/h2-13H,1H3,(H,26,27,28)	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>3.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Amgen, Inc. Curated by ChEMBL					Assay Description Inhibition of human Nav1.5 expressed in HEK293 cells assessed as inhibition of sodium current at holding potential of -125 mV measured for 3 to 5 min...				ACS Med Chem Lett 7: 1062-1067 (2016) Article DOI: 10.1021/acsmedchemlett.6b00243 BindingDB Entry DOI: 10.7270/Q2VM4F65
					More data for this Ligand-Target Pair