BDBM15411 4-(4-fluorophenyl)-5-(pyridin-4-yl)-1,3-oxazole::4-[4-(4-Fluorophenyl)-5-oxazolyl]-pyridine::Pyridine deriv. 9
SMILES: Fc1ccc(cc1)-c1ncoc1-c1ccncc1
InChI Key: InChIKey=NKWYMYOCYVDEFC-UHFFFAOYSA-N
Data: 2 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Mitogen-activated protein kinase 14 (Homo sapiens (Human)) | BDBM15411 (4-(4-fluorophenyl)-5-(pyridin-4-yl)-1,3-oxazole | ...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Patents | Article PubMed | n/a | n/a | 600 | n/a | n/a | n/a | n/a | n/a | n/a |
Syncom B.V. Curated by ChEMBL | Assay Description Inhibition of p38a MAPK (unknown origin) by radiometric assay | Bioorg Med Chem Lett 24: 1352-7 (2014) Article DOI: 10.1016/j.bmcl.2014.01.034 BindingDB Entry DOI: 10.7270/Q2D221KT | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Mitogen-activated protein kinase 14 (Homo sapiens (Human)) | BDBM15411 (4-(4-fluorophenyl)-5-(pyridin-4-yl)-1,3-oxazole | ...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Patents | Article PubMed | n/a | n/a | 1.46E+3 | n/a | n/a | n/a | n/a | 7.2 | 30 |
Pfizer | Assay Description The IC50s were determined by incubating each test compound with activated p38-alpha in a 96-well plate that had been pre-treated with ATF-2-GST to al... | J Med Chem 48: 5728-37 (2005) Article DOI: 10.1021/jm050346q BindingDB Entry DOI: 10.7270/Q2CR5RMP | |||||||||||
More data for this Ligand-Target Pair |