BDBM15412 5-[4-(4-Fluoro-phenyl)-oxazol-5-yl]-1-isopropyl-3-methyl-1,3-dihydrobenzoimidazol-2-one::5-[4-(4-fluorophenyl)-1,3-oxazol-5-yl]-3-methyl-1-(propan-2-yl)-2,3-dihydro-1H-1,3-benzodiazol-2-one::Benzimidazolone deriv. 15

SMILES: CC(C)n1c2ccc(cc2n(C)c1=O)-c1ocnc1-c1ccc(F)cc1

InChI Key: InChIKey=OXLPMUKQYFIPBW-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 15412   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Mitogen-activated protein kinase 14 (Homo sapiens (Human))	BDBM15412 (5-[4-(4-Fluoro-phenyl)-oxazol-5-yl]-1-isopropyl-3-...) Show SMILES CC(C)n1c2ccc(cc2n(C)c1=O)-c1ocnc1-c1ccc(F)cc1 Show InChI InChI=1S/C20H18FN3O2/c1-12(2)24-16-9-6-14(10-17(16)23(3)20(24)25)19-18(22-11-26-19)13-4-7-15(21)8-5-13/h4-12H,1-3H3	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	30	n/a	n/a	n/a	n/a	7.2	30
Pfizer					Assay Description The IC50s were determined by incubating each test compound with activated p38-alpha in a 96-well plate that had been pre-treated with ATF-2-GST to al...				J Med Chem 48: 5728-37 (2005) Article DOI: 10.1021/jm050346q BindingDB Entry DOI: 10.7270/Q2CR5RMP
					More data for this Ligand-Target Pair