BDBM154497 US9012443, 293

SMILES: COc1cc(ccc1-c1n[nH]c(=O)c2cc(ccc12)S(=O)(=O)Nc1nccs1)C(F)(F)F

InChI Key: InChIKey=LMIJVCDFGCEVCX-UHFFFAOYSA-N

Data: 4 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 154497   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Sodium channel protein type 9 subunit alpha (Homo sapiens (Human))	BDBM154497 (US9012443, 293) Show SMILES COc1cc(ccc1-c1n[nH]c(=O)c2cc(ccc12)S(=O)(=O)Nc1nccs1)C(F)(F)F Show InChI InChI=1S/C19H13F3N4O4S2/c1-30-15-8-10(19(20,21)22)2-4-13(15)16-12-5-3-11(9-14(12)17(27)25-24-16)32(28,29)26-18-23-6-7-31-18/h2-9H,1H3,(H,23,26)(H,25,27)	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	150	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc. US Patent					Assay Description 293 cells stably transfected with human Nav1.7 were recorded in whole cell voltage clamp mode with the PatchXpress automated electrophysiology system...				US Patent US9012443 (2015) BindingDB Entry DOI: 10.7270/Q2N0158J
					More data for this Ligand-Target Pair
Sodium channel protein type 9 subunit alpha (Homo sapiens (Human))	BDBM154497 (US9012443, 293) Show SMILES COc1cc(ccc1-c1n[nH]c(=O)c2cc(ccc12)S(=O)(=O)Nc1nccs1)C(F)(F)F Show InChI InChI=1S/C19H13F3N4O4S2/c1-30-15-8-10(19(20,21)22)2-4-13(15)16-12-5-3-11(9-14(12)17(27)25-24-16)32(28,29)26-18-23-6-7-31-18/h2-9H,1H3,(H,23,26)(H,25,27)	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	150	n/a	n/a	n/a	n/a	n/a	n/a
Amgen, Inc. Curated by ChEMBL					Assay Description Inhibition of human Nav1.7 expressed in HEK293 cells assessed as inhibition of sodium current at holding potential of -125 mV measured for 3 to 5 min...				ACS Med Chem Lett 7: 1062-1067 (2016) Article DOI: 10.1021/acsmedchemlett.6b00243 BindingDB Entry DOI: 10.7270/Q2VM4F65
					More data for this Ligand-Target Pair
Sodium channel protein type 5 subunit alpha (Homo sapiens (Human))	BDBM154497 (US9012443, 293) Show SMILES COc1cc(ccc1-c1n[nH]c(=O)c2cc(ccc12)S(=O)(=O)Nc1nccs1)C(F)(F)F Show InChI InChI=1S/C19H13F3N4O4S2/c1-30-15-8-10(19(20,21)22)2-4-13(15)16-12-5-3-11(9-14(12)17(27)25-24-16)32(28,29)26-18-23-6-7-31-18/h2-9H,1H3,(H,23,26)(H,25,27)	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>3.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Amgen, Inc. Curated by ChEMBL					Assay Description Inhibition of human Nav1.5 expressed in HEK293 cells assessed as inhibition of sodium current at holding potential of -125 mV measured for 3 to 5 min...				ACS Med Chem Lett 7: 1062-1067 (2016) Article DOI: 10.1021/acsmedchemlett.6b00243 BindingDB Entry DOI: 10.7270/Q2VM4F65
					More data for this Ligand-Target Pair
Sodium channel protein type 5 subunit alpha (Homo sapiens (Human))	BDBM154497 (US9012443, 293) Show SMILES COc1cc(ccc1-c1n[nH]c(=O)c2cc(ccc12)S(=O)(=O)Nc1nccs1)C(F)(F)F Show InChI InChI=1S/C19H13F3N4O4S2/c1-30-15-8-10(19(20,21)22)2-4-13(15)16-12-5-3-11(9-14(12)17(27)25-24-16)32(28,29)26-18-23-6-7-31-18/h2-9H,1H3,(H,23,26)(H,25,27)	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	>3.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc. US Patent					Assay Description 293 cells stably transfected with Nav 1.5 were recorded in whole cell voltage clamp mode with the PatchXpress automated electrophysiology system acco...				US Patent US9012443 (2015) BindingDB Entry DOI: 10.7270/Q2N0158J
					More data for this Ligand-Target Pair