null
SMILES: O=C(NCCN1CCC2(CC1)N(Cc1cccnc1)CNC2=O)c1ccc2ccccc2c1
InChI Key: InChIKey=VBJYNYMKFQGJCH-UHFFFAOYSA-N
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Phospholipase D1 (Homo sapiens (Human)) | BDBM154518 (ML395 (6)) | PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | >3.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Vanderbilt University | Assay Description Cells were seeded into 12-well tissue culture plates to reach 90% confluence at the time of assay. All cell types, aside from the HEK293-gfpPLD2 cell... | ACS Chem Biol 10: 421-32 (2015) Article DOI: 10.1021/cb500828m BindingDB Entry DOI: 10.7270/Q2H70DK8 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Phospholipase D2 (Homo sapiens (Human)) | BDBM154518 (ML395 (6)) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 380 | n/a | n/a | n/a | n/a | n/a | n/a |
Vanderbilt University | Assay Description Cells were seeded into 12-well tissue culture plates to reach 90% confluence at the time of assay. All cell types, aside from the HEK293-gfpPLD2 cell... | ACS Chem Biol 10: 421-32 (2015) Article DOI: 10.1021/cb500828m BindingDB Entry DOI: 10.7270/Q2H70DK8 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Phospholipase D2 (Homo sapiens (Human)) | BDBM154518 (ML395 (6)) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 360 | n/a | n/a | n/a | n/a | n/a | n/a |
Vanderbilt University Medical Center Curated by ChEMBL | Assay Description Inhibition of PLD2 (unknown origin) | Bioorg Med Chem Lett 28: 3670-3673 (2018) Article DOI: 10.1016/j.bmcl.2018.10.033 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Phospholipase D1 (Homo sapiens (Human)) | BDBM154518 (ML395 (6)) | PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | >3.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Vanderbilt University Medical Center Curated by ChEMBL | Assay Description Inhibition of PLD1 (unknown origin) | Bioorg Med Chem Lett 28: 3670-3673 (2018) Article DOI: 10.1016/j.bmcl.2018.10.033 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Phospholipase (Pseudomonas aeruginosa (g-Proteobacteria)) | BDBM154518 (ML395 (6)) | UniProtKB/TrEMBL GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | >2.00E+4 | n/a | n/a | n/a | n/a | 7.5 | n/a |
Vanderbilt University | Assay Description In brief, 6 nM purified PldA was incubated with liposomes containing 90 μM 1,2-dioleoyl-sn-glycero-3-phospho-(1′-rac-glycerol), 10 μM... | ACS Chem Biol 10: 421-32 (2015) Article DOI: 10.1021/cb500828m BindingDB Entry DOI: 10.7270/Q2H70DK8 | |||||||||||
More data for this Ligand-Target Pair |