null
SMILES: CN1CCN(Cc2ccc(NC(=O)c3cccc4cc(Oc5cc(NC(C)=O)ncn5)ccc34)cc2C(F)(F)F)CC1
InChI Key: InChIKey=MZZJNOOADWVFPD-UHFFFAOYSA-N
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Cyclin-dependent kinase 2 (Homo sapiens (Human)) | BDBM154577 (K03859 (2)) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase MCE PC cid PC sid UniChem | Article PubMed | n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | 303.15 |
University of Oxford | Assay Description For IC50 measurements, a 384-well microtiter plate contained 8-point serial dilutions of inhibitors and 16-point serial dilutions of staurosporine as... | ACS Chem Biol 10: 2116-25 (2015) Article DOI: 10.1021/acschembio.5b00398 BindingDB Entry DOI: 10.7270/Q2VH5MKH | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cyclin-dependent kinase 2 [F80T] (Homo sapiens (Human)) | BDBM154577 (K03859 (2)) | PDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | Purchase MCE PC cid PC sid UniChem | Article PubMed | n/a | n/a | 7.10E+3 | n/a | n/a | n/a | n/a | n/a | 303.15 |
University of Oxford | Assay Description For IC50 measurements, a 384-well microtiter plate contained 8-point serial dilutions of inhibitors and 16-point serial dilutions of staurosporine as... | ACS Chem Biol 10: 2116-25 (2015) Article DOI: 10.1021/acschembio.5b00398 BindingDB Entry DOI: 10.7270/Q2VH5MKH | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cyclin-dependent kinase 2 [F80M] (Homo sapiens (Human)) | BDBM154577 (K03859 (2)) | PDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | Purchase MCE PC cid PC sid UniChem | Article PubMed | n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | 303.15 |
University of Oxford | Assay Description For IC50 measurements, a 384-well microtiter plate contained 8-point serial dilutions of inhibitors and 16-point serial dilutions of staurosporine as... | ACS Chem Biol 10: 2116-25 (2015) Article DOI: 10.1021/acschembio.5b00398 BindingDB Entry DOI: 10.7270/Q2VH5MKH | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cyclin-dependent kinase 2 [C118L,A144C] (Homo sapiens (Human)) | BDBM154577 (K03859 (2)) | PDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | Purchase MCE PC cid PC sid UniChem | Article PubMed | n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | 303.15 |
University of Oxford | Assay Description For IC50 measurements, a 384-well microtiter plate contained 8-point serial dilutions of inhibitors and 16-point serial dilutions of staurosporine as... | ACS Chem Biol 10: 2116-25 (2015) Article DOI: 10.1021/acschembio.5b00398 BindingDB Entry DOI: 10.7270/Q2VH5MKH | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cyclin-dependent kinase 2 [C118I] (Homo sapiens (Human)) | BDBM154577 (K03859 (2)) | PDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | Purchase MCE PC cid PC sid UniChem | Article PubMed | n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | 303.15 |
University of Oxford | Assay Description For IC50 measurements, a 384-well microtiter plate contained 8-point serial dilutions of inhibitors and 16-point serial dilutions of staurosporine as... | ACS Chem Biol 10: 2116-25 (2015) Article DOI: 10.1021/acschembio.5b00398 BindingDB Entry DOI: 10.7270/Q2VH5MKH | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cyclin-dependent kinase 2 [A144C] (Homo sapiens (Human)) | BDBM154577 (K03859 (2)) | PDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | Purchase MCE PC cid PC sid UniChem | Article PubMed | n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | 303.15 |
University of Oxford | Assay Description For IC50 measurements, a 384-well microtiter plate contained 8-point serial dilutions of inhibitors and 16-point serial dilutions of staurosporine as... | ACS Chem Biol 10: 2116-25 (2015) Article DOI: 10.1021/acschembio.5b00398 BindingDB Entry DOI: 10.7270/Q2VH5MKH | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cyclin-dependent kinase 2 [A144G] (Homo sapiens (Human)) | BDBM154577 (K03859 (2)) | PDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | Purchase MCE PC cid PC sid UniChem | Article PubMed | n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | 303.15 |
University of Oxford | Assay Description For IC50 measurements, a 384-well microtiter plate contained 8-point serial dilutions of inhibitors and 16-point serial dilutions of staurosporine as... | ACS Chem Biol 10: 2116-25 (2015) Article DOI: 10.1021/acschembio.5b00398 BindingDB Entry DOI: 10.7270/Q2VH5MKH | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cyclin-dependent kinase 2 [C118L] (Homo sapiens (Human)) | BDBM154577 (K03859 (2)) | PDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | Purchase MCE PC cid PC sid UniChem | Article PubMed | n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | 303.15 |
University of Oxford | Assay Description For IC50 measurements, a 384-well microtiter plate contained 8-point serial dilutions of inhibitors and 16-point serial dilutions of staurosporine as... | ACS Chem Biol 10: 2116-25 (2015) Article DOI: 10.1021/acschembio.5b00398 BindingDB Entry DOI: 10.7270/Q2VH5MKH | |||||||||||
More data for this Ligand-Target Pair |