BDBM154579 (2S)-2-[(2S)-2-hexanamido-3-methylbutanamido]-N,N-dimethyl-N'-[(2S)-4-methyl-1-[(2R)-2-methyloxiran-2-yl]-1-oxopentan-2-yl]pentanediamide (3)::(2S)-N-[(4S)-2,6-dimethyl-3-oxohept-1-en-4-yl]-2-[(2S)-2-hexanamido-3-methylbutanamido]-N',N'-dimethylpentanediamide (4)
SMILES: CCCCCC(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCC(=O)N(C)C)C(=O)N[C@@H](CC(C)C)C(=O)[C@@]1(C)CO1
InChI Key: InChIKey=VVLGADWOLFDWLU-HATFTNJXSA-N
Data: 4 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
20S proteasome (Saccharomyces cerevisiae s288c (Yeast)) | BDBM154579 ((2S)-2-[(2S)-2-hexanamido-3-methylbutanamido]-N,N-...) | PDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 1.20 | n/a | n/a | n/a | n/a | 7.5 | n/a |
University of California at San Diego; University of Campinas | Assay Description One nanomolar of proteasome was incubated with different inhibitor concentrations in Tris 25 mM pH 7.5; SDS 0.03%; EDTA 0.5 mM for 15 min at 37 °C in... | Chem Biol 21: 782-91 (2014) Article DOI: 10.1016/j.chembiol.2014.04.010 BindingDB Entry DOI: 10.7270/Q2QR4VVS | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
20S proteasome (Saccharomyces cerevisiae s288c (Yeast)) | BDBM154579 ((2S)-2-[(2S)-2-hexanamido-3-methylbutanamido]-N,N-...) | PDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | >5.00E+4 | n/a | n/a | n/a | n/a | 7.5 | n/a |
University of California at San Diego; University of Campinas | Assay Description One nanomolar of proteasome was incubated with different inhibitor concentrations in Tris 25 mM pH 7.5; SDS 0.03%; EDTA 0.5 mM for 15 min at 37 °C in... | Chem Biol 21: 782-91 (2014) Article DOI: 10.1016/j.chembiol.2014.04.010 BindingDB Entry DOI: 10.7270/Q2QR4VVS | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
20S proteasome (Saccharomyces cerevisiae s288c (Yeast)) | BDBM154579 ((2S)-2-[(2S)-2-hexanamido-3-methylbutanamido]-N,N-...) | PDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 112 | n/a | n/a | n/a | n/a | 7.5 | n/a |
University of California at San Diego; University of Campinas | Assay Description One nanomolar of proteasome was incubated with different inhibitor concentrations in Tris 25 mM pH 7.5; SDS 0.03%; EDTA 0.5 mM for 15 min at 37 °C in... | Chem Biol 21: 782-91 (2014) Article DOI: 10.1016/j.chembiol.2014.04.010 BindingDB Entry DOI: 10.7270/Q2QR4VVS | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
20S proteasome (Saccharomyces cerevisiae s288c (Yeast)) | BDBM154579 ((2S)-2-[(2S)-2-hexanamido-3-methylbutanamido]-N,N-...) | PDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 165 | n/a | n/a | n/a | n/a | 7.5 | n/a |
University of California at San Diego; University of Campinas | Assay Description One nanomolar of proteasome was incubated with different inhibitor concentrations in Tris 25 mM pH 7.5; SDS 0.03%; EDTA 0.5 mM for 15 min at 37 °C in... | Chem Biol 21: 782-91 (2014) Article DOI: 10.1016/j.chembiol.2014.04.010 BindingDB Entry DOI: 10.7270/Q2QR4VVS | |||||||||||
More data for this Ligand-Target Pair |