BDBM154582 6-[4-({[(1R)-1-(isoquinolin-8-yl)ethyl]amino}methyl)phenyl]pyridine-3-carboxylic acid (Compound 2)
SMILES: C[C@@H](NCc1ccc(cc1)-c1ccc(cn1)C(O)=O)c1cccc2ccncc12
InChI Key: InChIKey=IVXJMWGSLJKPFD-MRXNPFEDSA-N
Data: 7 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
AMP deaminase 1 (hAMPD1) (Homo sapiens (Human)) | BDBM154582 (6-[4-({[(1R)-1-(isoquinolin-8-yl)ethyl]amino}methy...) | KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 9.20E+3 | n/a | n/a | n/a | n/a | 7.4 | n/a |
AstraZeneca R&D | Assay Description AMPD1 was added to buffer A (50 mM HEPES, 150 mM KCl, 5 mM MgCl2, and 0.5 mMglutathione [pH 7.4]) to a concentration of 10 nM. A substrate mix consis... | Chem Biol 21: 1486-96 (2014) Article DOI: 10.1016/j.chembiol.2014.09.011 BindingDB Entry DOI: 10.7270/Q2M0445M | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
AMP deaminase 1 (rAMPD1) (Rattus norvegicus (Rat)) | BDBM154582 (6-[4-({[(1R)-1-(isoquinolin-8-yl)ethyl]amino}methy...) | KEGG UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 5.80E+3 | n/a | n/a | n/a | n/a | 7.4 | n/a |
AstraZeneca R&D | Assay Description AMPD1 was added to buffer A (50 mM HEPES, 150 mM KCl, 5 mM MgCl2, and 0.5 mMglutathione [pH 7.4]) to a concentration of 10 nM. A substrate mix consis... | Chem Biol 21: 1486-96 (2014) Article DOI: 10.1016/j.chembiol.2014.09.011 BindingDB Entry DOI: 10.7270/Q2M0445M | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
AMP deaminase 1 (mAMPD1) (Mus musculus (Mouse)) | BDBM154582 (6-[4-({[(1R)-1-(isoquinolin-8-yl)ethyl]amino}methy...) | KEGG UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 4.50E+3 | n/a | n/a | n/a | n/a | 7.4 | n/a |
AstraZeneca R&D | Assay Description AMPD1 was added to buffer A (50 mM HEPES, 150 mM KCl, 5 mM MgCl2, and 0.5 mMglutathione [pH 7.4]) to a concentration of 10 nM. A substrate mix consis... | Chem Biol 21: 1486-96 (2014) Article DOI: 10.1016/j.chembiol.2014.09.011 BindingDB Entry DOI: 10.7270/Q2M0445M | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
AMP deaminase 3 (rAMPD3) (Rattus norvegicus (Rat)) | BDBM154582 (6-[4-({[(1R)-1-(isoquinolin-8-yl)ethyl]amino}methy...) | KEGG UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 4.40E+4 | n/a | n/a | n/a | n/a | 7.4 | n/a |
AstraZeneca R&D | Assay Description AMPD1 was added to buffer A (50 mM HEPES, 150 mM KCl, 5 mM MgCl2, and 0.5 mMglutathione [pH 7.4]) to a concentration of 10 nM. A substrate mix consis... | Chem Biol 21: 1486-96 (2014) Article DOI: 10.1016/j.chembiol.2014.09.011 BindingDB Entry DOI: 10.7270/Q2M0445M | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
AMP deaminase 2 (rAMPD2) (Rattus norvegicus (Rat)) | BDBM154582 (6-[4-({[(1R)-1-(isoquinolin-8-yl)ethyl]amino}methy...) | KEGG UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 3.20E+4 | n/a | n/a | n/a | n/a | 7.4 | n/a |
AstraZeneca R&D | Assay Description AMPD1 was added to buffer A (50 mM HEPES, 150 mM KCl, 5 mM MgCl2, and 0.5 mMglutathione [pH 7.4]) to a concentration of 10 nM. A substrate mix consis... | Chem Biol 21: 1486-96 (2014) Article DOI: 10.1016/j.chembiol.2014.09.011 BindingDB Entry DOI: 10.7270/Q2M0445M | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
AMP deaminase 3 (hAMPD3) (Homo sapiens (Human)) | BDBM154582 (6-[4-({[(1R)-1-(isoquinolin-8-yl)ethyl]amino}methy...) | KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 7.30E+3 | n/a | n/a | n/a | n/a | 7.4 | n/a |
AstraZeneca R&D | Assay Description AMPD1 was added to buffer A (50 mM HEPES, 150 mM KCl, 5 mM MgCl2, and 0.5 mMglutathione [pH 7.4]) to a concentration of 10 nM. A substrate mix consis... | Chem Biol 21: 1486-96 (2014) Article DOI: 10.1016/j.chembiol.2014.09.011 BindingDB Entry DOI: 10.7270/Q2M0445M | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
AMP deaminase 2 (Homo sapiens (Human)) | BDBM154582 (6-[4-({[(1R)-1-(isoquinolin-8-yl)ethyl]amino}methy...) | KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 3.20E+4 | n/a | n/a | n/a | n/a | 7.4 | n/a |
AstraZeneca R&D | Assay Description AMPD1 was added to buffer A (50 mM HEPES, 150 mM KCl, 5 mM MgCl2, and 0.5 mMglutathione [pH 7.4]) to a concentration of 10 nM. A substrate mix consis... | Chem Biol 21: 1486-96 (2014) Article DOI: 10.1016/j.chembiol.2014.09.011 BindingDB Entry DOI: 10.7270/Q2M0445M | |||||||||||
More data for this Ligand-Target Pair |