BDBM155565 US10092556, Example 1::US9012475, 1::US9346787, 1
SMILES: Cc1cc(Nc2nc(CC3(CCN(CC3)C(=O)c3cccc(Cl)c3Cl)C(O)=O)ccc2F)n[nH]1
InChI Key: InChIKey=PLAVWQHGBMTMFR-UHFFFAOYSA-N
Data: 6 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Aurora kinase A (Homo sapiens (Human)) | BDBM155565 (US10092556, Example 1 | US9012475, 1 | US9346787, ...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase MCE PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 0.400 | n/a | n/a | n/a | n/a | 7.4 | 25 |
Taiho Pharmaceutical Co., Ltd. US Patent | Assay Description An inhibitory activity of the above compound in-vitro against Aurora A kinase activity was measured with reference to a method described in JP-A-2008... | US Patent US9012475 (2015) BindingDB Entry DOI: 10.7270/Q2MW2FWZ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Aurora kinase B (Homo sapiens (Human)) | BDBM155565 (US10092556, Example 1 | US9012475, 1 | US9346787, ...) | PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | Purchase MCE PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 140 | n/a | n/a | n/a | n/a | 7.4 | n/a |
Taiho Pharmaceutical Co., Ltd. US Patent | Assay Description The method for measuring the in-vitro inhibitory activity of a test compound against Aurora B kinase activity was substantially the same as in the ca... | US Patent US9012475 (2015) BindingDB Entry DOI: 10.7270/Q2MW2FWZ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Aurora kinase B (Homo sapiens (Human)) | BDBM155565 (US10092556, Example 1 | US9012475, 1 | US9346787, ...) | PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | Purchase MCE PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 140 | n/a | n/a | n/a | n/a | 7.4 | n/a |
TAIHO PHARMACEUTICAL CO., LTD. US Patent | Assay Description The in vitro method for measuring the inhibitory activity of the test compound on the aurora B kinase activity was performed in a similar manner as t... | US Patent US10092556 (2018) BindingDB Entry DOI: 10.7270/Q2ZG6V8B | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Aurora kinase B (Homo sapiens (Human)) | BDBM155565 (US10092556, Example 1 | US9012475, 1 | US9346787, ...) | PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | Purchase MCE PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 140 | n/a | n/a | n/a | n/a | 7.4 | n/a |
TAIHO PHARMACEUTICAL CO., LTD. US Patent | Assay Description The in vitro method for measuring the inhibitory activity of the test compound on the aurora B kinase activity was performed in a similar manner as t... | US Patent US9346787 (2016) BindingDB Entry DOI: 10.7270/Q28K77Z2 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Aurora kinase A (Homo sapiens (Human)) | BDBM155565 (US10092556, Example 1 | US9012475, 1 | US9346787, ...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase MCE PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 0.400 | n/a | n/a | n/a | n/a | 7.4 | 25 |
TAIHO PHARMACEUTICAL CO., LTD. US Patent | Assay Description For in vitro method for measuring the inhibitory activity of the aforementioned compounds on the aurora A kinase activity was carried out referring t... | US Patent US10092556 (2018) BindingDB Entry DOI: 10.7270/Q2ZG6V8B | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Aurora kinase A (Homo sapiens (Human)) | BDBM155565 (US10092556, Example 1 | US9012475, 1 | US9346787, ...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase MCE PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 0.400 | n/a | n/a | n/a | n/a | 7.4 | 25 |
TAIHO PHARMACEUTICAL CO., LTD. US Patent | Assay Description For in vitro method for measuring the inhibitory activity of the aforementioned compounds on the aurora A kinase activity was carried out referring t... | US Patent US9346787 (2016) BindingDB Entry DOI: 10.7270/Q28K77Z2 | |||||||||||
More data for this Ligand-Target Pair |