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BDBM155926 US9018211, 20

SMILES: COc1cc(ccc1C#N)C(O)CN1CCN(CCc2ccc3C(=O)OCc3c2)CC1

InChI Key: InChIKey=XIZPZXOLRNGWLR-UHFFFAOYNA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 155926   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Renal Outer Medullary Potassium (ROMK)


(Rattus norvegicus (Rat))
BDBM155926
PNG
(US9018211, 20)
Show SMILES COc1cc(ccc1C#N)C(O)CN1CCN(CCc2ccc3C(=O)OCc3c2)CC1
Show InChI InChI=1/C24H27N3O4/c1-30-23-13-18(3-4-19(23)14-25)22(28)15-27-10-8-26(9-11-27)7-6-17-2-5-21-20(12-17)16-31-24(21)29/h2-5,12-13,22,28H,6-11,15-16H2,1H3
UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 14n/an/an/an/a7.4n/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
Block of Kir 1.1 (ROMKl) currents was examined by whole cell voltage clamp (Hamill et. al. Pfluegers Archives 391 : 85- 100 (1981)) using the IonWork...


US Patent US9018211 (2015)


BindingDB Entry DOI: 10.7270/Q2CC0ZDS
More data for this
Ligand-Target Pair