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SMILES: Clc1cccc(Cl)c1C(=O)OCC(=C)C(=O)NCc1ccccc1

InChI Key: InChIKey=BHOIUKUCMCAJGO-UHFFFAOYSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 156238   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Thioredoxin reductase 1, cytoplasmic


(Homo sapiens (Human))		BDBM156238
PNG
(US9018255, 8b)
Show SMILES Clc1cccc(Cl)c1C(=O)OCC(=C)C(=O)NCc1ccccc1
Show InChI InChI=1S/C18H15Cl2NO3/c1-12(17(22)21-10-13-6-3-2-4-7-13)11-24-18(23)16-14(19)8-5-9-15(16)20/h2-9H,1,10-11H2,(H,21,22)
PDB

KEGG

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PC cid
PC sid
UniChem
US Patent
n/an/a 5.90E+3n/an/an/an/a7.6n/a



Instytut Chemii Organicznej Polskiej Akademii Nauk; Warszawski Uniwersytet Medyczny

US Patent


Assay Description
The method of determining thioredoxin activity is based on the reduction of insulin by thioredoxin. Thioredoxin is reconstituted is by thioredoxin re...

US Patent US9018255 (2015)


BindingDB Entry DOI: 10.7270/Q2VD6X6N
More data for this
Ligand-Target Pair