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BDBM158889 US9034866, 364

SMILES: NC(=O)c1cn2C3CC(C3)c3cc(F)c(cc3-c2n1)C#CC1(O)CCC1

InChI Key: InChIKey=JFANDWARWGAZSM-UHFFFAOYSA-N

Data: 1 KI

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 158889   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Mitogen-activated protein kinase kinase kinase 14


(Homo sapiens (Human))		BDBM158889
PNG
(US9034866, 364)
Show SMILES NC(=O)c1cn2C3CC(C3)c3cc(F)c(cc3-c2n1)C#CC1(O)CCC1 |(-3.88,4.09,;-4.97,3,;-6.46,3.4,;-4.58,1.51,;-5.59,.35,;-4.8,-.97,;-5.47,-2.36,;-4.8,-3.75,;-3.3,-4.09,;-3.85,-2.36,;-2.09,-3.13,;-.76,-3.9,;.57,-3.13,;1.91,-3.9,;.57,-1.59,;-.76,-.82,;-2.09,-1.59,;-3.3,-.63,;-3.16,.91,;1.91,-.82,;3.24,-.05,;4.58,.72,;3.24,1.49,;6.06,.32,;6.46,1.81,;4.97,2.21,)|
Show InChI InChI=1S/C20H18FN3O2/c21-16-9-14-12-6-13(7-12)24-10-17(18(22)25)23-19(24)15(14)8-11(16)2-5-20(26)3-1-4-20/h8-10,12-13,26H,1,3-4,6-7H2,(H2,22,25)
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PC cid
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UniChem

Similars
US Patent
 0.530n/an/an/an/an/an/a7.2n/a



Genentech, Inc.

US Patent


Assay Description
The ability of the nuclear factor-kappa B (NF-kB)-inducing kinase (NIK) to catalyze the hydrolysis of adenosine-5'-triphosphate (ATP) was monitored u...

US Patent US9034866 (2015)


BindingDB Entry DOI: 10.7270/Q2GX49B0
More data for this
Ligand-Target Pair