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SMILES: OC(=O)c1cc(ccc1C(=O)Nc1ncc(cc1Cl)C(F)(F)F)C(F)(F)F

InChI Key: InChIKey=DYPLYEPDUGMASY-UHFFFAOYSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 159138   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Sortilin (Homo sapiens (Human))	BDBM159138 (US10195186, Example 16 | US9682967, 16) Show SMILES OC(=O)c1cc(ccc1C(=O)Nc1ncc(cc1Cl)C(F)(F)F)C(F)(F)F Show InChI InChI=1S/C15H7ClF6N2O3/c16-10-4-7(15(20,21)22)5-23-11(10)24-12(25)8-2-1-6(14(17,18)19)3-9(8)13(26)27/h1-5H,(H,26,27)(H,23,24,25)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	343	n/a	360	n/a	n/a	n/a	n/a	7.4	n/a
H. Lundbeck A/S US Patent					Assay Description The Sortilin assay was performed in total volume of 40 ul in 50 mM HEPES pH 7.4 assay buffer containing 100 mM NaCl, 2.0 mM CaCl2, 0.1% BSA and 0.1% ...				US Patent US9682967 (2017) BindingDB Entry DOI: 10.7270/Q22805SC
					More data for this Ligand-Target Pair
Sortilin (Homo sapiens (Human))	BDBM159138 (US10195186, Example 16 | US9682967, 16) Show SMILES OC(=O)c1cc(ccc1C(=O)Nc1ncc(cc1Cl)C(F)(F)F)C(F)(F)F Show InChI InChI=1S/C15H7ClF6N2O3/c16-10-4-7(15(20,21)22)5-23-11(10)24-12(25)8-2-1-6(14(17,18)19)3-9(8)13(26)27/h1-5H,(H,26,27)(H,23,24,25)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	343	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
H. Lundbeck A/S US Patent					Assay Description The Sortilin assay was performed in total volume of 40 ul in 50 mM HEPES pH 7.4 assay buffer containing 100 mM NaCl, 2.0 mM CaCl2, 0.1% BSA and 0.1% ...				US Patent US10195186 (2019) BindingDB Entry DOI: 10.7270/Q2474CZW
					More data for this Ligand-Target Pair
Sortilin (Homo sapiens (Human))	BDBM159138 (US10195186, Example 16 | US9682967, 16) Show SMILES OC(=O)c1cc(ccc1C(=O)Nc1ncc(cc1Cl)C(F)(F)F)C(F)(F)F Show InChI InChI=1S/C15H7ClF6N2O3/c16-10-4-7(15(20,21)22)5-23-11(10)24-12(25)8-2-1-6(14(17,18)19)3-9(8)13(26)27/h1-5H,(H,26,27)(H,23,24,25)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	360	n/a	n/a	n/a	n/a	n/a	n/a
H. Lundbeck A/S US Patent					Assay Description The Sortilin assay was performed in total volume of 40 ul in 50 mM HEPES pH 7.4 assay buffer containing 100 mM NaCl, 2.0 mM CaCl2, 0.1% BSA and 0.1% ...				US Patent US10195186 (2019) BindingDB Entry DOI: 10.7270/Q2474CZW
					More data for this Ligand-Target Pair