BDBM159170 US9034866, 647

SMILES: CN1CC[C@@](O)(C#Cc2ccc3OC[C@H](O)c4sc(nc4-c3c2)C(N)=O)C1=O

InChI Key: InChIKey=LCQFWABXVYPPQW-BUXKBTBVSA-N

Data: 2 KI

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 159170   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Mitogen-activated protein kinase kinase kinase 14 (Homo sapiens (Human))	BDBM159170 (US9034866, 647) Show SMILES CN1CC[C@@](O)(C#Cc2ccc3OC[C@H](O)c4sc(nc4-c3c2)C(N)=O)C1=O |r| Show InChI InChI=1S/C19H17N3O5S/c1-22-7-6-19(26,18(22)25)5-4-10-2-3-13-11(8-10)14-15(12(23)9-27-13)28-17(21-14)16(20)24/h2-3,8,12,23,26H,6-7,9H2,1H3,(H2,20,24)/t12-,19-/m0/s1	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	0.400	n/a	n/a	n/a	n/a	n/a	n/a	7.2	n/a
Genentech, Inc. US Patent					Assay Description The ability of the nuclear factor-kappa B (NF-kB)-inducing kinase (NIK) to catalyze the hydrolysis of adenosine-5'-triphosphate (ATP) was monitored u...				US Patent US9034866 (2015) BindingDB Entry DOI: 10.7270/Q2GX49B0
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 14 (Homo sapiens (Human))	BDBM159170 (US9034866, 647) Show SMILES CN1CC[C@@](O)(C#Cc2ccc3OC[C@H](O)c4sc(nc4-c3c2)C(N)=O)C1=O |r| Show InChI InChI=1S/C19H17N3O5S/c1-22-7-6-19(26,18(22)25)5-4-10-2-3-13-11(8-10)14-15(12(23)9-27-13)28-17(21-14)16(20)24/h2-3,8,12,23,26H,6-7,9H2,1H3,(H2,20,24)/t12-,19-/m0/s1	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	0.600	n/a	n/a	n/a	n/a	n/a	n/a	7.2	n/a
Genentech, Inc. US Patent					Assay Description The ability of the nuclear factor-kappa B (NF-kB)-inducing kinase (NIK) to catalyze the hydrolysis of adenosine-5'-triphosphate (ATP) was monitored u...				US Patent US9034866 (2015) BindingDB Entry DOI: 10.7270/Q2GX49B0
					More data for this Ligand-Target Pair