BDBM160756 US9682980, 8-Chloro-7-(4-(2,4-dimethoxyphenyl)piperidin-1-yl)-3-(2,2,2-trifluoroethyl)-[1,2,4]triazolo[4,3-b]pyridazine

SMILES: COc1ccc(C2CCN(CC2)c2cnn3c(CC(F)(F)F)nnc3c2Cl)c(OC)c1

InChI Key: InChIKey=OHALEEPDDOZJQN-UHFFFAOYSA-N

Data: 1 EC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 160756   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Metabotropic glutamate receptor 2 (Homo sapiens (Human))	BDBM160756 (US9682980, 8-Chloro-7-(4-(2,4-dimethoxyphenyl)pipe...) Show SMILES COc1ccc(C2CCN(CC2)c2cnn3c(CC(F)(F)F)nnc3c2Cl)c(OC)c1 Show InChI InChI=1S/C20H21ClF3N5O2/c1-30-13-3-4-14(16(9-13)31-2)12-5-7-28(8-6-12)15-11-25-29-17(10-20(22,23)24)26-27-19(29)18(15)21/h3-4,9,11-12H,5-8,10H2,1-2H3	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	5	n/a	n/a	7.0	n/a
Bristol-Myers Squibb Company US Patent					Assay Description Clonally expressed human mGluR2 in HEK293 background was glutamate starved overnight in media without glutamine (GIBCO MEM 12360), containing 10% FBS...				US Patent US9682980 (2017) BindingDB Entry DOI: 10.7270/Q2J964JS
					More data for this Ligand-Target Pair