BDBM160772 US9682980, 8-Chloro-3-(cyclopropylmethyl)-7-(4-(2-(difluoromethoxy)-3,6-difluorophenyl)piperidin-1-yl)-[1,2,4]triazolo[4,3-b]pyridazine

SMILES: FC(F)Oc1c(F)ccc(F)c1C1CCN(CC1)c1cnn2c(CC3CC3)nnc2c1Cl

InChI Key: InChIKey=URSHKHJSJQXTFC-UHFFFAOYSA-N

Data: 1 EC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 160772   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Metabotropic glutamate receptor 2 (Homo sapiens (Human))	BDBM160772 (US9682980, 8-Chloro-3-(cyclopropylmethyl)-7-(4-(2-...) Show SMILES FC(F)Oc1c(F)ccc(F)c1C1CCN(CC1)c1cnn2c(CC3CC3)nnc2c1Cl Show InChI InChI=1S/C21H20ClF4N5O/c22-18-15(10-27-31-16(9-11-1-2-11)28-29-20(18)31)30-7-5-12(6-8-30)17-13(23)3-4-14(24)19(17)32-21(25)26/h3-4,10-12,21H,1-2,5-9H2	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	2	n/a	n/a	7.0	n/a
Bristol-Myers Squibb Company US Patent					Assay Description Clonally expressed human mGluR2 in HEK293 background was glutamate starved overnight in media without glutamine (GIBCO MEM 12360), containing 10% FBS...				US Patent US9682980 (2017) BindingDB Entry DOI: 10.7270/Q2J964JS
					More data for this Ligand-Target Pair