BDBM161329 US10087143, Compound 114::US10738009, Compound 114::US10787472, Compound 1a::US9051270, 114::US9163042, 1a::US9758483, Compound 114
SMILES: COc1cc(F)ccc1Oc1cc(Cl)c(Cl)cc1C(=O)Nc1cc[nH]c(=O)c1
InChI Key: InChIKey=CSKLRKQUNQCFCW-UHFFFAOYSA-N
Data: 6 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Voltage-gated sodium channel subunit alpha Nav1.8 (Rattus norvegicus (Rat)) | BDBM161329 (US10087143, Compound 114 | US10738009, Compound 11...) | PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 1 | n/a | n/a | n/a | n/a | n/a | n/a |
VERTEX PHARMACEUTICALS INCORPORATED US Patent | Assay Description Patch clamp electrophysiology was used to assess the efficacy and selectivity of sodium channel blockers in dorsal root ganglion neurons. Rat neurons... | US Patent US9051270 (2015) BindingDB Entry DOI: 10.7270/Q2B27T1F | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Voltage-gated sodium channel subunit alpha Nav1.8 (Rattus norvegicus (Rat)) | BDBM161329 (US10087143, Compound 114 | US10738009, Compound 11...) | PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 1 | n/a | n/a | n/a | n/a | n/a | n/a |
VERTEX PHARMACEUTICALS INCORPORATED US Patent | Assay Description Patch clamp electrophysiology was used to assess the efficacy and selectivity of sodium channel blockers in dorsal root ganglion neurons. Rat neurons... | US Patent US9163042 (2015) BindingDB Entry DOI: 10.7270/Q21Z4361 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium channel alpha subunit (Homo sapiens (Human)) | BDBM161329 (US10087143, Compound 114 | US10738009, Compound 11...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 1 | n/a | n/a | n/a | n/a | n/a | n/a |
Vertex Pharmaceuticals Incorporated US Patent | Assay Description Patch clamp electrophysiology was used to assess the efficacy and selectivity of sodium channel blockers in dorsal root ganglion neurons. Rat neurons... | US Patent US10787472 (2020) | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium channel protein type 10 subunit alpha (Homo sapiens (Human)) | BDBM161329 (US10087143, Compound 114 | US10738009, Compound 11...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 1 | n/a | n/a | n/a | n/a | n/a | n/a |
VERTEX PHARMACEUTICALS INCORPORATED US Patent | Assay Description 1) Pre-spotted compounds (in neat DMSO) into compound plates. Vehicle control (neat DMSO), the positive control (20 mM DMSO stock tetracaine, 125 ... | US Patent US9758483 (2017) BindingDB Entry DOI: 10.7270/Q28C9ZCT | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium channel alpha subunit (Homo sapiens (Human)) | BDBM161329 (US10087143, Compound 114 | US10738009, Compound 11...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 1 | n/a | n/a | n/a | n/a | n/a | n/a |
VERTEX PHARMACEUTICALS INCORPORATED US Patent | Assay Description Patch clamp electrophysiology was used to assess the efficacy and selectivity of sodium channel blockers in dorsal root ganglion neurons. Rat neurons... | US Patent US10738009 (2020) | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium channel protein type 10 subunit alpha (Homo sapiens (Human)) | BDBM161329 (US10087143, Compound 114 | US10738009, Compound 11...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 1 | n/a | n/a | n/a | n/a | n/a | n/a |
VERTEX PHARMACEUTICALS INCORPORATED US Patent | Assay Description Sodium channels are voltage-dependent proteins that can be activated by inducing membrane voltage changes by applying electric fields. The electrical... | US Patent US10087143 (2018) BindingDB Entry DOI: 10.7270/Q2HD7XP6 | |||||||||||
More data for this Ligand-Target Pair |