null

SMILES: COc1cc(OC)cc(c1)C#Cc1nn([C@H]2C[C@@H](C#C)N(C2)C(=O)C=C)c2ncnc(N)c12

InChI Key: InChIKey=QIGKMOZLJKDFKI-SJORKVTESA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 161419   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Fibroblast growth factor receptor 2 (Homo sapiens (Human))	BDBM161419 (US10124003, Ex. Compound 32 | US10835536, Ex. Comp...) Show SMILES COc1cc(OC)cc(c1)C#Cc1nn([C@H]2C[C@@H](C#C)N(C2)C(=O)C=C)c2ncnc(N)c12 |r| Show InChI InChI=1S/C24H22N6O3/c1-5-16-11-17(13-29(16)21(31)6-2)30-24-22(23(25)26-14-27-24)20(28-30)8-7-15-9-18(32-3)12-19(10-15)33-4/h1,6,9-10,12,14,16-17H,2,11,13H2,3-4H3,(H2,25,26,27)/t16-,17+/m1/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	0.400	n/a	n/a	n/a	n/a	7.5	25
Taiho Pharmaceutical Co., Ltd. US Patent					Assay Description When setting conditions for the measurement of the inhibitory effect of the compounds on FGFR2 kinase activity, FL-Peptide 22 (Caliper Life Sciences,...				US Patent US9108973 (2015) BindingDB Entry DOI: 10.7270/Q2XW4HJV
					More data for this Ligand-Target Pair
Fibroblast growth factor receptor 2 (Homo sapiens (Human))	BDBM161419 (US10124003, Ex. Compound 32 | US10835536, Ex. Comp...) Show SMILES COc1cc(OC)cc(c1)C#Cc1nn([C@H]2C[C@@H](C#C)N(C2)C(=O)C=C)c2ncnc(N)c12 |r| Show InChI InChI=1S/C24H22N6O3/c1-5-16-11-17(13-29(16)21(31)6-2)30-24-22(23(25)26-14-27-24)20(28-30)8-7-15-9-18(32-3)12-19(10-15)33-4/h1,6,9-10,12,14,16-17H,2,11,13H2,3-4H3,(H2,25,26,27)/t16-,17+/m1/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	0.400	n/a	n/a	n/a	n/a	n/a	n/a
Taiho Pharmaceutical Co., Ltd. US Patent					Assay Description When setting conditions for the measurement of the inhibitory effect of the compounds on FGFR2 kinase activity, FL-Peptide 22 (Caliper Life Sciences,...				US Patent US10894048 (2021)
					More data for this Ligand-Target Pair
Fibroblast growth factor receptor 2 (Homo sapiens (Human))	BDBM161419 (US10124003, Ex. Compound 32 | US10835536, Ex. Comp...) Show SMILES COc1cc(OC)cc(c1)C#Cc1nn([C@H]2C[C@@H](C#C)N(C2)C(=O)C=C)c2ncnc(N)c12 |r| Show InChI InChI=1S/C24H22N6O3/c1-5-16-11-17(13-29(16)21(31)6-2)30-24-22(23(25)26-14-27-24)20(28-30)8-7-15-9-18(32-3)12-19(10-15)33-4/h1,6,9-10,12,14,16-17H,2,11,13H2,3-4H3,(H2,25,26,27)/t16-,17+/m1/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	0.400	n/a	n/a	n/a	n/a	n/a	n/a
Taiho Pharmaceutical Co., Ltd. US Patent					Assay Description When setting conditions for the measurement of the inhibitory effect of the compounds on FGFR2 kinase activity, FL-Peptide 22 (Caliper Life Sciences,...				US Patent US10835536 (2020)
					More data for this Ligand-Target Pair
Fibroblast growth factor receptor 2 (Homo sapiens (Human))	BDBM161419 (US10124003, Ex. Compound 32 | US10835536, Ex. Comp...) Show SMILES COc1cc(OC)cc(c1)C#Cc1nn([C@H]2C[C@@H](C#C)N(C2)C(=O)C=C)c2ncnc(N)c12 |r| Show InChI InChI=1S/C24H22N6O3/c1-5-16-11-17(13-29(16)21(31)6-2)30-24-22(23(25)26-14-27-24)20(28-30)8-7-15-9-18(32-3)12-19(10-15)33-4/h1,6,9-10,12,14,16-17H,2,11,13H2,3-4H3,(H2,25,26,27)/t16-,17+/m1/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	0.400	n/a	n/a	n/a	n/a	n/a	n/a
Taiho Pharmaceutical Co., Ltd. US Patent					Assay Description When setting conditions for the measurement of the inhibitory effect of the compounds on FGFR2 kinase activity, FL-Peptide 22 (Caliper Life Sciences,...				US Patent US10124003 (2018) BindingDB Entry DOI: 10.7270/Q2B27XBQ
					More data for this Ligand-Target Pair