BDBM16147 (2S)-2-({4-chloro-1-[(diaminomethylidene)amino]isoquinoline-7-}sulfonamido)propanoic acid::substituted glycine deriv. 21

SMILES: [#6]-[#6@H](-[#7]S(=O)(=O)c1ccc2c(Cl)cnc(\[#7]=[#6](/[#7])-[#7])c2c1)-[#6](-[#8])=O

InChI Key: InChIKey=WCTDCNDFJVKKHF-LURJTMIESA-N

Data: 2 KI

PDB links: 1 PDB ID contains this monomer as substructures. 1 PDB ID contains inhibitors having a similarity of 90% to this monomer.

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 16147   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Urokinase-type plasminogen activator (Homo sapiens (Human))	BDBM16147 ((2S)-2-({4-chloro-1-[(diaminomethylidene)amino]iso...) Show SMILES [#6]-[#6@H](-[#7]S(=O)(=O)c1ccc2c(Cl)cnc(\[#7]=[#6](/[#7])-[#7])c2c1)-[#6](-[#8])=O |r| Show InChI InChI=1S/C13H14ClN5O4S/c1-6(12(20)21)19-24(22,23)7-2-3-8-9(4-7)11(18-13(15)16)17-5-10(8)14/h2-6,19H,1H3,(H,20,21)(H4,15,16,17,18)/t6-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	21	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer					Assay Description Ki values for compounds were calculated by incubation of each enzyme with its substrate and various compound concentrations. Absorbance was read at 4...				J Med Chem 50: 2341-51 (2007) Article DOI: 10.1021/jm061066t BindingDB Entry DOI: 10.7270/Q27S7M18
					More data for this Ligand-Target Pair
Plasminogen (Homo sapiens (Human))	BDBM16147 ((2S)-2-({4-chloro-1-[(diaminomethylidene)amino]iso...) Show SMILES [#6]-[#6@H](-[#7]S(=O)(=O)c1ccc2c(Cl)cnc(\[#7]=[#6](/[#7])-[#7])c2c1)-[#6](-[#8])=O |r| Show InChI InChI=1S/C13H14ClN5O4S/c1-6(12(20)21)19-24(22,23)7-2-3-8-9(4-7)11(18-13(15)16)17-5-10(8)14/h2-6,19H,1H3,(H,20,21)(H4,15,16,17,18)/t6-/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	1.50E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer					Assay Description Ki values for compounds were calculated by incubation of each enzyme with its substrate and various compound concentrations. Absorbance was read at 4...				J Med Chem 50: 2341-51 (2007) Article DOI: 10.1021/jm061066t BindingDB Entry DOI: 10.7270/Q27S7M18
					More data for this Ligand-Target Pair