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SMILES: Cc1c(cc(-c2cc(Cl)ccc2C(=O)N2Cc3ccccc3C[C@H]2CN2CCOCC2)n1C)C(=O)N(c1cnn(c1)C1COC1)c1ccc(O)cc1

InChI Key: InChIKey=ABNPERFMBJHFSK-HKBQPEDESA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 161560   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Apoptosis regulator Bcl-2


(Homo sapiens (Human))		BDBM161560
PNG
(US9108983, Example 126)
Show SMILES Cc1c(cc(-c2cc(Cl)ccc2C(=O)N2Cc3ccccc3C[C@H]2CN2CCOCC2)n1C)C(=O)N(c1cnn(c1)C1COC1)c1ccc(O)cc1
Show InChI InChI=1S/C40H41ClN6O5/c1-26-36(40(50)47(30-8-10-34(48)11-9-30)32-20-42-46(23-32)33-24-52-25-33)19-38(43(26)2)37-18-29(41)7-12-35(37)39(49)45-21-28-6-4-3-5-27(28)17-31(45)22-44-13-15-51-16-14-44/h3-12,18-20,23,31,33,48H,13-17,21-22,24-25H2,1-2H3/t31-/m0/s1
PDB

UniProtKB/SwissProt

antibodypedia
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AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 4.20n/an/an/an/a7.4n/a



LES LABORATOIRES SERVIER; VERNALIS (R&D) LTD

US Patent


Assay Description
The fluorescence polarisation tests were carried out on microplates (384 wells). The Bcl-2 protein, labelled (histag-Bcl-2 such that Bcl-2 correspond...

US Patent US9108983 (2015)


BindingDB Entry DOI: 10.7270/Q2PC314Z
More data for this
Ligand-Target Pair