BDBM161573 US9108983, Example 388::US9108984, 2
SMILES: CN1CCc2cc(cnc12)N(C(=O)c1cc(-c2cc(Cl)ccc2C(=O)N2Cc3ccccc3C[C@H]2CN2CCOCC2)n(C)c1C)c1ccc(O)cc1
InChI Key: InChIKey=DWAFEVLSULNKRI-UMSFTDKQSA-N
Data: 2 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform (Homo sapiens (Human)) | BDBM161573 (US9108983, Example 388 | US9108984, 2) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | <20 | n/a | n/a | n/a | n/a | 6.7 | 25 |
Incyte Corporation; Incyte Holdings Corporation US Patent | Assay Description The kinase reaction was conducted in polystyrene 384-well matrix white plate from Thermo Fisher Scientific in a final volume of 25 uL. Inhibitors wer... | US Patent US9108984 (2015) BindingDB Entry DOI: 10.7270/Q2JM28CS | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Apoptosis regulator Bcl-2 (Homo sapiens (Human)) | BDBM161573 (US9108983, Example 388 | US9108984, 2) | PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 3.60 | n/a | n/a | n/a | n/a | 7.4 | n/a |
LES LABORATOIRES SERVIER; VERNALIS (R&D) LTD US Patent | Assay Description The fluorescence polarisation tests were carried out on microplates (384 wells). The Bcl-2 protein, labelled (histag-Bcl-2 such that Bcl-2 correspond... | US Patent US9108983 (2015) BindingDB Entry DOI: 10.7270/Q2PC314Z | |||||||||||
More data for this Ligand-Target Pair |