BDBM161640 US9108983, Example 460

SMILES: Cc1c(cc(-c2cc(Cl)ccc2C(=O)N2Cc3ccccc3C[C@H]2CCCN2CCOCC2)n1C)C(=O)N(c1cnn(c1)C1CCOC1)c1ccc(O)cc1

InChI Key: InChIKey=NMIDCYCADXHHTR-IFDNYZKCSA-N

Data: 1 IC50

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Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 161640   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Apoptosis regulator Bcl-2 (Homo sapiens (Human))	BDBM161640 (US9108983, Example 460) Show SMILES Cc1c(cc(-c2cc(Cl)ccc2C(=O)N2Cc3ccccc3C[C@H]2CCCN2CCOCC2)n1C)C(=O)N(c1cnn(c1)C1CCOC1)c1ccc(O)cc1 Show InChI InChI=1S/C43H47ClN6O5/c1-29-39(43(53)50(33-10-12-37(51)13-11-33)36-25-45-49(27-36)35-15-19-55-28-35)24-41(46(29)2)40-23-32(44)9-14-38(40)42(52)48-26-31-7-4-3-6-30(31)22-34(48)8-5-16-47-17-20-54-21-18-47/h3-4,6-7,9-14,23-25,27,34-35,51H,5,8,15-22,26,28H2,1-2H3/t34-,35?/m1/s1	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	2.80	n/a	n/a	n/a	n/a	7.4	n/a
LES LABORATOIRES SERVIER; VERNALIS (R&D) LTD US Patent					Assay Description The fluorescence polarisation tests were carried out on microplates (384 wells). The Bcl-2 protein, labelled (histag-Bcl-2 such that Bcl-2 correspond...				US Patent US9108983 (2015) BindingDB Entry DOI: 10.7270/Q2PC314Z
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