BDBM16167 2-(4-chloro-7-{[1-(hydroxymethyl)cyclopentyl]sulfamoyl}isoquinolin-1-yl)guanidine::cycloleucine deriv. 41

SMILES: [#7]\[#6](-[#7])=[#7]/c1ncc(Cl)c2ccc(cc12)S(=O)(=O)[#7]C1([#6]-[#8])[#6]-[#6]-[#6]-[#6]1

InChI Key: InChIKey=NLAQBJIOBYDJOU-UHFFFAOYSA-N

Data: 1 KI

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 16167   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Urokinase-type plasminogen activator (Homo sapiens (Human))	BDBM16167 (2-(4-chloro-7-{[1-(hydroxymethyl)cyclopentyl]sulfa...) Show SMILES [#7]\[#6](-[#7])=[#7]/c1ncc(Cl)c2ccc(cc12)S(=O)(=O)[#7]C1([#6]-[#8])[#6]-[#6]-[#6]-[#6]1 Show InChI InChI=1S/C16H20ClN5O3S/c17-13-8-20-14(21-15(18)19)12-7-10(3-4-11(12)13)26(24,25)22-16(9-23)5-1-2-6-16/h3-4,7-8,22-23H,1-2,5-6,9H2,(H4,18,19,20,21)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	67	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer					Assay Description Ki values for compounds were calculated by incubation of each enzyme with its substrate and various compound concentrations. Absorbance was read at 4...				J Med Chem 50: 2341-51 (2007) Article DOI: 10.1021/jm061066t BindingDB Entry DOI: 10.7270/Q27S7M18
					More data for this Ligand-Target Pair