BDBM16168 1-({4-chloro-1-[(diaminomethylidene)amino]isoquinoline-7-}sulfonamido)-N-[2-(dimethylamino)ethyl]cyclopentane-1-carboxamide::cycloleucine deriv. 42
SMILES: [#6]-[#7](-[#6])-[#6]-[#6]-[#7]-[#6](=O)C1([#6]-[#6]-[#6]-[#6]1)[#7]S(=O)(=O)c1ccc2c(Cl)cnc(\[#7]=[#6](/[#7])-[#7])c2c1
InChI Key: InChIKey=LDQBNBQEPZPATR-UHFFFAOYSA-N
Data: 2 KI
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Urokinase-type plasminogen activator (Homo sapiens (Human)) | BDBM16168 (1-({4-chloro-1-[(diaminomethylidene)amino]isoquino...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Patents Similars | Article PubMed | 30 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer | Assay Description Ki values for compounds were calculated by incubation of each enzyme with its substrate and various compound concentrations. Absorbance was read at 4... | J Med Chem 50: 2341-51 (2007) Article DOI: 10.1021/jm061066t BindingDB Entry DOI: 10.7270/Q27S7M18 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Plasminogen (Homo sapiens (Human)) | BDBM16168 (1-({4-chloro-1-[(diaminomethylidene)amino]isoquino...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Patents Similars | Article PubMed | >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer | Assay Description Ki values for compounds were calculated by incubation of each enzyme with its substrate and various compound concentrations. Absorbance was read at 4... | J Med Chem 50: 2341-51 (2007) Article DOI: 10.1021/jm061066t BindingDB Entry DOI: 10.7270/Q27S7M18 | |||||||||||
More data for this Ligand-Target Pair |