null

SMILES: CC[C@@H](C)Oc1cc2C(N(C(=O)Cc2cc1OC)c1ccc(cc1)N(C)CC1CCCN(C)C1)c1ccc(Cl)cc1

InChI Key: InChIKey=FMWULHHMNFVCEP-MPFIGGLTSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 161875   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Protein Mdm4 (Homo sapiens (Human))	BDBM161875 (US9051279, 46) Show SMILES CC[C@@H](C)Oc1cc2C(N(C(=O)Cc2cc1OC)c1ccc(cc1)N(C)CC1CCCN(C)C1)c1ccc(Cl)cc1 |r| Show InChI InChI=1S/C34H42ClN3O3/c1-6-23(2)41-32-20-30-26(18-31(32)40-5)19-33(39)38(34(30)25-9-11-27(35)12-10-25)29-15-13-28(14-16-29)37(4)22-24-8-7-17-36(3)21-24/h9-16,18,20,23-24,34H,6-8,17,19,21-22H2,1-5H3/t23-,24?,34?/m1/s1	PDB MMDB NCI pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	1.04E+4	n/a	n/a	n/a	n/a	n/a	n/a
Novartis AG US Patent					Assay Description The inhibition of p53-Hdm2 and p53-Hdm4 interactions is measured by time resolved fluorescence energy transfer (TR-FRET). Fluorescence energy transfe...				US Patent US9051279 (2015) BindingDB Entry DOI: 10.7270/Q2DV1HMM
					More data for this Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2 (Homo sapiens (Human))	BDBM161875 (US9051279, 46) Show SMILES CC[C@@H](C)Oc1cc2C(N(C(=O)Cc2cc1OC)c1ccc(cc1)N(C)CC1CCCN(C)C1)c1ccc(Cl)cc1 |r| Show InChI InChI=1S/C34H42ClN3O3/c1-6-23(2)41-32-20-30-26(18-31(32)40-5)19-33(39)38(34(30)25-9-11-27(35)12-10-25)29-15-13-28(14-16-29)37(4)22-24-8-7-17-36(3)21-24/h9-16,18,20,23-24,34H,6-8,17,19,21-22H2,1-5H3/t23-,24?,34?/m1/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	9.10	n/a	n/a	n/a	n/a	n/a	n/a
Novartis AG US Patent					Assay Description The inhibition of p53-Hdm2 and p53-Hdm4 interactions is measured by time resolved fluorescence energy transfer (TR-FRET). Fluorescence energy transfe...				US Patent US9051279 (2015) BindingDB Entry DOI: 10.7270/Q2DV1HMM
					More data for this Ligand-Target Pair