BDBM161948 US9051279, 59

SMILES: CC[C@@H](C)Oc1cc2C(N(C(=O)Cc2cc1OC)c1ccc(cc1)C(C)N(CC)C(=O)C1CCN(CC1)C(C)=O)c1ccc(Cl)cc1

InChI Key: InChIKey=WGYKJEFTTXDLPM-YFTDMWITSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 161948   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
p53-Binding Protein HDMX (Homo sapiens (Human))	BDBM161948 (US9051279, 59) Show SMILES CC[C@@H](C)Oc1cc2C(N(C(=O)Cc2cc1OC)c1ccc(cc1)C(C)N(CC)C(=O)C1CCN(CC1)C(C)=O)c1ccc(Cl)cc1 |r| Show InChI InChI=1S/C38H46ClN3O5/c1-7-24(3)47-35-23-33-30(21-34(35)46-6)22-36(44)42(37(33)28-9-13-31(39)14-10-28)32-15-11-27(12-16-32)25(4)41(8-2)38(45)29-17-19-40(20-18-29)26(5)43/h9-16,21,23-25,29,37H,7-8,17-20,22H2,1-6H3/t24-,25?,37?/m1/s1	PDB MMDB NCI pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	2.91E+4	n/a	n/a	n/a	n/a	n/a	n/a
Novartis AG US Patent					Assay Description The inhibition of p53-Hdm2 and p53-Hdm4 interactions is measured by time resolved fluorescence energy transfer (TR-FRET). Fluorescence energy transfe...				US Patent US9051279 (2015) BindingDB Entry DOI: 10.7270/Q2DV1HMM
					More data for this Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2 (Homo sapiens (Human))	BDBM161948 (US9051279, 59) Show SMILES CC[C@@H](C)Oc1cc2C(N(C(=O)Cc2cc1OC)c1ccc(cc1)C(C)N(CC)C(=O)C1CCN(CC1)C(C)=O)c1ccc(Cl)cc1 |r| Show InChI InChI=1S/C38H46ClN3O5/c1-7-24(3)47-35-23-33-30(21-34(35)46-6)22-36(44)42(37(33)28-9-13-31(39)14-10-28)32-15-11-27(12-16-32)25(4)41(8-2)38(45)29-17-19-40(20-18-29)26(5)43/h9-16,21,23-25,29,37H,7-8,17-20,22H2,1-6H3/t24-,25?,37?/m1/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	51.2	n/a	n/a	n/a	n/a	n/a	n/a
Novartis AG US Patent					Assay Description The inhibition of p53-Hdm2 and p53-Hdm4 interactions is measured by time resolved fluorescence energy transfer (TR-FRET). Fluorescence energy transfe...				US Patent US9051279 (2015) BindingDB Entry DOI: 10.7270/Q2DV1HMM
					More data for this Ligand-Target Pair