BDBM161951 US9051279, 61

SMILES: CC[C@@H](C)Oc1cc2C(N(C(=O)Cc2cc1OC)c1ccc(cc1)C(C)NC1CCNCC1)c1ccc(Cl)cc1

InChI Key: InChIKey=KHAYFXPJPHDPRJ-KGUSEGQSSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 161951   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
p53-Binding Protein HDMX (Homo sapiens (Human))	BDBM161951 (US9051279, 61) Show SMILES CC[C@@H](C)Oc1cc2C(N(C(=O)Cc2cc1OC)c1ccc(cc1)C(C)NC1CCNCC1)c1ccc(Cl)cc1 |r| Show InChI InChI=1S/C33H40ClN3O3/c1-5-21(2)40-31-20-29-25(18-30(31)39-4)19-32(38)37(33(29)24-6-10-26(34)11-7-24)28-12-8-23(9-13-28)22(3)36-27-14-16-35-17-15-27/h6-13,18,20-22,27,33,35-36H,5,14-17,19H2,1-4H3/t21-,22?,33?/m1/s1	PDB MMDB NCI pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	3.08E+4	n/a	n/a	n/a	n/a	n/a	n/a
Novartis AG US Patent					Assay Description The inhibition of p53-Hdm2 and p53-Hdm4 interactions is measured by time resolved fluorescence energy transfer (TR-FRET). Fluorescence energy transfe...				US Patent US9051279 (2015) BindingDB Entry DOI: 10.7270/Q2DV1HMM
					More data for this Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2 (Homo sapiens (Human))	BDBM161951 (US9051279, 61) Show SMILES CC[C@@H](C)Oc1cc2C(N(C(=O)Cc2cc1OC)c1ccc(cc1)C(C)NC1CCNCC1)c1ccc(Cl)cc1 |r| Show InChI InChI=1S/C33H40ClN3O3/c1-5-21(2)40-31-20-29-25(18-30(31)39-4)19-32(38)37(33(29)24-6-10-26(34)11-7-24)28-12-8-23(9-13-28)22(3)36-27-14-16-35-17-15-27/h6-13,18,20-22,27,33,35-36H,5,14-17,19H2,1-4H3/t21-,22?,33?/m1/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	42.6	n/a	n/a	n/a	n/a	n/a	n/a
Novartis AG US Patent					Assay Description The inhibition of p53-Hdm2 and p53-Hdm4 interactions is measured by time resolved fluorescence energy transfer (TR-FRET). Fluorescence energy transfe...				US Patent US9051279 (2015) BindingDB Entry DOI: 10.7270/Q2DV1HMM
					More data for this Ligand-Target Pair