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SMILES: CC(C)NC1CC2(C1)CCN(CC2)c1nn2c(nnc2c2OCCN(C)c12)-c1cccc(OC(F)(F)F)c1

InChI Key: InChIKey=SWXVTYYUSJWLLO-UHFFFAOYSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 162031   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))		BDBM162031
PNG
(US9682991, 87)
Show SMILES CC(C)NC1CC2(C1)CCN(CC2)c1nn2c(nnc2c2OCCN(C)c12)-c1cccc(OC(F)(F)F)c1
Show InChI InChI=1S/C26H32F3N7O2/c1-16(2)30-18-14-25(15-18)7-9-35(10-8-25)23-20-21(37-12-11-34(20)3)24-32-31-22(36(24)33-23)17-5-4-6-19(13-17)38-26(27,28)29/h4-6,13,16,18,30H,7-12,14-15H2,1-3H3
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US Patent
n/an/a<100n/an/an/an/an/an/a



FUNDACIÓN CENTRO NACIONAL DE INVESTIGACIONES ONCOLOGICAS CARLOS III

US Patent


Assay Description
The biochemical assay to measure PIM-1 activity relies on the ADP Hunter assay kit (DiscoveRx Corp., Cat. #90-0077), that determines the amount of AD...

US Patent US9682991 (2017)


BindingDB Entry DOI: 10.7270/Q2513WCB
More data for this
Ligand-Target Pair