BDBM162174 US9682995, 73
SMILES: CCNC(=O)c1cncc(Nc2snc(C)c2C(=O)Nc2ccc(F)c(F)c2)n1
InChI Key: InChIKey=FVBCNOGCHOUKDH-UHFFFAOYSA-N
Data: 3 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
CDK2/CycE (Homo sapiens (Human)) | BDBM162174 (US9682995, 73) | PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | >2.00E+4 | n/a | n/a | n/a | n/a | 7.5 | 22 |
BAYER PHARMA AKTIENGESELLSCHAFT US Patent | Assay Description N-terminally His6-tagged recombinant catalytic domain of human Bub1 (amino acids 704-1085), expressed in insect cells (Hi5) and purified by Ni-NTA af... | US Patent US9682995 (2017) BindingDB Entry DOI: 10.7270/Q2WH2N5Q | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Dual specificity protein kinase TTK (Homo sapiens (Human)) | BDBM162174 (US9682995, 73) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | >2.00E+4 | n/a | n/a | n/a | n/a | 7.7 | 22 |
BAYER PHARMA AKTIENGESELLSCHAFT US Patent | Assay Description N-terminally GST-tagged human full length recombinant Mps-1 kinase (purchased from Invitrogen, Karslruhe, Germany, cat. no PV4071) was used. As subst... | US Patent US9682995 (2017) BindingDB Entry DOI: 10.7270/Q2WH2N5Q | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Mitotic checkpoint serine/threonine-protein kinase BUB1 (aa 704-1085) (Homo sapiens (Human)) | BDBM162174 (US9682995, 73) | PDB GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 6.20E+3 | n/a | n/a | n/a | n/a | 8.0 | n/a |
BAYER PHARMA AKTIENGESELLSCHAFT US Patent | Assay Description Recombinant fusion proteins of GST and human CDK2 and of GST and human CycE, expressed in insect cells (Sf9) and purified by Glutathion-Sepharose aff... | US Patent US9682995 (2017) BindingDB Entry DOI: 10.7270/Q2WH2N5Q | |||||||||||
More data for this Ligand-Target Pair |