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SMILES: FC(F)(F)c1nc(no1)-c1ccc(cc1)C(=O)NC1CCCC1

InChI Key: InChIKey=QNOFNGIYSBDWCK-UHFFFAOYSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 162738   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Histone deacetylase 1 (Homo sapiens (Human))	BDBM162738 (US9056843, 29) Show SMILES FC(F)(F)c1nc(no1)-c1ccc(cc1)C(=O)NC1CCCC1 Show InChI InChI=1S/C15H14F3N3O2/c16-15(17,18)14-20-12(21-23-14)9-5-7-10(8-6-9)13(22)19-11-3-1-2-4-11/h5-8,11H,1-4H2,(H,19,22)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase PC cid PC sid UniChem Similars	US Patent	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	8.0	25
NOVARTIS AG US Patent					Assay Description A similar assay procedure as described in Test 2 was used for HDAC1. Human recombinant full length HDAC1 expressed in a baculovirus expression system...				US Patent US9056843 (2015) BindingDB Entry DOI: 10.7270/Q24F1PG8
					More data for this Ligand-Target Pair
Histone deacetylase 6 (Homo sapiens (Human))	BDBM162738 (US9056843, 29) Show SMILES FC(F)(F)c1nc(no1)-c1ccc(cc1)C(=O)NC1CCCC1 Show InChI InChI=1S/C15H14F3N3O2/c16-15(17,18)14-20-12(21-23-14)9-5-7-10(8-6-9)13(22)19-11-3-1-2-4-11/h5-8,11H,1-4H2,(H,19,22)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase PC cid PC sid UniChem Similars	US Patent	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	8.0	25
NOVARTIS AG US Patent					Assay Description A similar assay procedure as described in Test 2 was used for HDAC6. Human recombinant full length HDAC6 expressed in a baculovirus expression system...				US Patent US9056843 (2015) BindingDB Entry DOI: 10.7270/Q24F1PG8
					More data for this Ligand-Target Pair
Histone deacetylase 4 (Homo sapiens (Human))	BDBM162738 (US9056843, 29) Show SMILES FC(F)(F)c1nc(no1)-c1ccc(cc1)C(=O)NC1CCCC1 Show InChI InChI=1S/C15H14F3N3O2/c16-15(17,18)14-20-12(21-23-14)9-5-7-10(8-6-9)13(22)19-11-3-1-2-4-11/h5-8,11H,1-4H2,(H,19,22)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase PC cid PC sid UniChem Similars	US Patent	n/a	n/a	1.20E+3	n/a	n/a	n/a	n/a	8.0	25
NOVARTIS AG US Patent					Assay Description Human recombinant HDAC4 was expressed in full length form (aa 2-1084) in Sf9 insect cells (obtained from ATCC) using baculovirus generated with Bac-t...				US Patent US9056843 (2015) BindingDB Entry DOI: 10.7270/Q24F1PG8
					More data for this Ligand-Target Pair