BDBM163026 US9056865, A-153

SMILES: Cc1cc(F)cnc1-c1cc(ncc1Cl)N1CCC(CC1)NS(=O)(=O)CC(C)(C)O

InChI Key: InChIKey=AWJHRWCVUAAGRU-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 163026   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
G-protein- coupled-like receptor Smoothened (Smo) (Homo sapiens (Human))	BDBM163026 (US9056865, A-153) Show SMILES Cc1cc(F)cnc1-c1cc(ncc1Cl)N1CCC(CC1)NS(=O)(=O)CC(C)(C)O Show InChI InChI=1S/C20H26ClFN4O3S/c1-13-8-14(22)10-24-19(13)16-9-18(23-11-17(16)21)26-6-4-15(5-7-26)25-30(28,29)12-20(2,3)27/h8-11,15,25,27H,4-7,12H2,1-3H3	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	10.6	n/a	n/a	n/a	n/a	n/a	25
Pfizer Inc. US Patent					Assay Description For the binding competition assay, 100 μL of Assay Buffer was added to all the wells of a 96 well GF/B filter plate (Millipore MultiScreen-HTS-F...				US Patent US9056865 (2015) BindingDB Entry DOI: 10.7270/Q2R49PH7
					More data for this Ligand-Target Pair