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SMILES: CCOc1nc(N)nc2n(cnc12)[C@@H]1O[C@@H]2COP(=O)(OC2[C@@]1(C)F)C(C)C

InChI Key: InChIKey=LZAMBKJSMJQLGV-GDFWUUSOSA-N

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   Substructure
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 163037   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Genome polyprotein


(Hepatitis C virus (HCV genotype 1a, isolate H))		BDBM163037
PNG
(US9061041, Compound C)
Show SMILES CCOc1nc(N)nc2n(cnc12)[C@@H]1O[C@@H]2COP(=O)(OC2[C@@]1(C)F)C(C)C |r|
Show InChI InChI=1S/C16H23FN5O5P/c1-5-24-13-10-12(20-15(18)21-13)22(7-19-10)14-16(4,17)11-9(26-14)6-25-28(23,27-11)8(2)3/h7-9,11,14H,5-6H2,1-4H3,(H2,18,20,21)/t9-,11?,14-,16-,28?/m1/s1
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PC cid
PC sid
UniChem
US Patent
 30 -10.3n/an/an/an/an/a7.325



Merck Sharp & Dohme Corp.

US Patent


Assay Description
To measure inhibition of the enzymatic activity of the HCV NS5B RNA-dependent RNA polymerase by the nucleoside triphosphate compounds of the present ...

US Patent US9061041 (2015)


BindingDB Entry DOI: 10.7270/Q2GM862K
More data for this
Ligand-Target Pair