null
SMILES: NC(=N)c1ccc2nc(Cc3ccccn3)[nH]c2c1
InChI Key: InChIKey=MHSMXTLGYPLSJM-UHFFFAOYSA-N
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Coagulation factor X (Homo sapiens (Human)) | BDBM16307 (2-(pyridin-2-ylmethyl)-1H-1,3-benzodiazole-6-carbo...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | 60 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Celera Curated by ChEMBL | Assay Description Binding affinity to FXa in presence of Zn2+ | Bioorg Med Chem Lett 16: 710-3 (2005) Article DOI: 10.1016/j.bmcl.2005.10.023 BindingDB Entry DOI: 10.7270/Q2VM4BSJ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tryptase beta-2 (Homo sapiens (Human)) | BDBM16307 (2-(pyridin-2-ylmethyl)-1H-1,3-benzodiazole-6-carbo...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | 310 | -8.78 | n/a | n/a | n/a | n/a | n/a | 8.2 | 22 |
Arris | Assay Description Enzymes were incubated with inhibitors at eight inhibitor concentrations bracketing the Ki, prepared by serial dilution along with control lacking th... | Nature 391: 608-12 (1998) Article DOI: 10.1038/35422 BindingDB Entry DOI: 10.7270/Q29P2ZW9 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Prothrombin (Homo sapiens (Human)) | BDBM16307 (2-(pyridin-2-ylmethyl)-1H-1,3-benzodiazole-6-carbo...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | 1.05E+4 | -6.72 | n/a | n/a | n/a | n/a | n/a | 8.2 | 22 |
Arris | Assay Description Enzymes were incubated with inhibitors at eight inhibitor concentrations bracketing the Ki, prepared by serial dilution along with control lacking th... | Nature 391: 608-12 (1998) Article DOI: 10.1038/35422 BindingDB Entry DOI: 10.7270/Q29P2ZW9 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Prothrombin (Homo sapiens (Human)) | BDBM16307 (2-(pyridin-2-ylmethyl)-1H-1,3-benzodiazole-6-carbo...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | 1.05E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Celera Curated by ChEMBL | Assay Description Binding affinity to thrombin in presence of Zn2+ | Bioorg Med Chem Lett 16: 710-3 (2005) Article DOI: 10.1016/j.bmcl.2005.10.023 BindingDB Entry DOI: 10.7270/Q2VM4BSJ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Coagulation factor VII (Homo sapiens (Human)) | BDBM16307 (2-(pyridin-2-ylmethyl)-1H-1,3-benzodiazole-6-carbo...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | 3.90E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Celera Curated by ChEMBL | Assay Description Binding affinity to FVIIa in presence of Zn2+ | Bioorg Med Chem Lett 16: 710-3 (2005) Article DOI: 10.1016/j.bmcl.2005.10.023 BindingDB Entry DOI: 10.7270/Q2VM4BSJ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Serine protease 1 (Homo sapiens (Human)) | BDBM16307 (2-(pyridin-2-ylmethyl)-1H-1,3-benzodiazole-6-carbo...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | 1.36E+5 | -5.22 | n/a | n/a | n/a | n/a | n/a | 8.2 | 22 |
Arris | Assay Description Enzymes were incubated with inhibitors at eight inhibitor concentrations bracketing the Ki, prepared by serial dilution along with control lacking th... | Nature 391: 608-12 (1998) Article DOI: 10.1038/35422 BindingDB Entry DOI: 10.7270/Q29P2ZW9 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Coagulation factor X (Homo sapiens (Human)) | BDBM16307 (2-(pyridin-2-ylmethyl)-1H-1,3-benzodiazole-6-carbo...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | >1.50E+5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Celera Curated by ChEMBL | Assay Description Binding affinity to FXa in absence of Zn2+ | Bioorg Med Chem Lett 16: 710-3 (2005) Article DOI: 10.1016/j.bmcl.2005.10.023 BindingDB Entry DOI: 10.7270/Q2VM4BSJ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Prothrombin (Homo sapiens (Human)) | BDBM16307 (2-(pyridin-2-ylmethyl)-1H-1,3-benzodiazole-6-carbo...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | >1.50E+5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Celera Curated by ChEMBL | Assay Description Binding affinity to thrombin in absence of Zn2+ | Bioorg Med Chem Lett 16: 710-3 (2005) Article DOI: 10.1016/j.bmcl.2005.10.023 BindingDB Entry DOI: 10.7270/Q2VM4BSJ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tryptase beta-2 (Homo sapiens (Human)) | BDBM16307 (2-(pyridin-2-ylmethyl)-1H-1,3-benzodiazole-6-carbo...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | 3.58E+5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Arris | Assay Description Enzymes were incubated with inhibitors at eight inhibitor concentrations bracketing the Ki, prepared by serial dilution along with control lacking th... | Nature 391: 608-12 (1998) Article DOI: 10.1038/35422 BindingDB Entry DOI: 10.7270/Q29P2ZW9 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Serine protease 1 (Homo sapiens (Human)) | BDBM16307 (2-(pyridin-2-ylmethyl)-1H-1,3-benzodiazole-6-carbo...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | >1.00E+6 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Arris | Assay Description Enzymes were incubated with inhibitors at eight inhibitor concentrations bracketing the Ki, prepared by serial dilution along with control lacking th... | Nature 391: 608-12 (1998) Article DOI: 10.1038/35422 BindingDB Entry DOI: 10.7270/Q29P2ZW9 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Prothrombin (Homo sapiens (Human)) | BDBM16307 (2-(pyridin-2-ylmethyl)-1H-1,3-benzodiazole-6-carbo...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | >1.00E+6 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Arris | Assay Description Enzymes were incubated with inhibitors at eight inhibitor concentrations bracketing the Ki, prepared by serial dilution along with control lacking th... | Nature 391: 608-12 (1998) Article DOI: 10.1038/35422 BindingDB Entry DOI: 10.7270/Q29P2ZW9 | |||||||||||
More data for this Ligand-Target Pair |